Ro 106-9920

Discontinued Product

1778 has been discontinued.
View all NFkB/IkB Inhibitors products.
Ro 106-9920 | CAS No. 62645-28-7 | NFkB/IkB Inhibitors
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Description: Inhibitor of NF-κB activation

Chemical Name: 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine

Purity: ≥99%

Product Details
Citations (4)

Biological Activity

Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

Technical Data

Soluble to 5 mM in ethanol and to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Anticancer agents. XII. Pyridazine and benzodiazine derivatives.
    Conalty et al.
    Proc.R.Ir.Acad.B., 1976;76:151
  2. A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats.
    Swinney et al.
    J.Biol.Chem., 2002;277:23573
  3. Glucocorticoid modulation of MUC5AC secretion in H292 cells.
    Baginski et al.
    Am.Soc.Cell Biol.Abstr., 2002;:765

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Citations for Ro 106-9920

The citations listed below are publications that use Tocris products. Selected citations for Ro 106-9920 include:

4 Citations: Showing 1 - 4


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