Chemical Name: 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine
Biological ActivityRo 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Anticancer agents. XII. Pyridazine and benzodiazine derivatives.
Conalty et al.
A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats.
Swinney et al.
Glucocorticoid modulation of MUC5AC secretion in H292 cells.
Baginski et al.
Am.Soc.Cell Biol.Abstr., 2002;:765
Citations for Ro 106-9920
The citations listed below are publications that use Tocris products. Selected citations for Ro 106-9920 include:
4 Citations: Showing 1 - 4
Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease.
Authors: Siew Et al.
Nat Commun 2019;10:3473
ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells.
Authors: Huang Et al.
J Inflamm (Lond) 2015;12:31
Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes.
Authors: Marinelli Et al.
PLoS One 2015;12:244
Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs.
Authors: Lapponi Et al.
J Pharmacol Exp Ther 2013;345:430
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