Inhibitor of NF-κ
B activation, possibly via selective inhibition of LPS- and TNF-α
= 3 μ
M). Blocks subsequent production of TNF-α
and IL-6. Inhibits mucin production in an in vitro
model of COPD, and is anti-inflammatory following oral administration in vivo
. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
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All Tocris products are intended for laboratory research use only.
Anticancer agents. XII. Pyridazine and benzodiazine derivatives.
Conalty et al.
A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats.
Swinney et al.
Glucocorticoid modulation of MUC5AC secretion in H292 cells.
Baginski et al.
Am.Soc.Cell Biol.Abstr., 2002;:765
The citations listed below are publications that use Tocris products. Selected citations for Ro 106-9920 include:
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