Chemical Name: 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine
Biological ActivityInhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Anticancer agents. XII. Pyridazine and benzodiazine derivatives.
Conalty et al.
A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats.
Swinney et al.
Glucocorticoid modulation of MUC5AC secretion in H292 cells.
Baginski et al.
Am.Soc.Cell Biol.Abstr., 2002;:765
Citations for Ro 106-9920
The citations listed below are publications that use Tocris products. Selected citations for Ro 106-9920 include:
3 Citations: Showing 1 - 3
ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells.
Authors: Huang Et al.
J Inflamm (Lond) 2015;12:31
Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes.
Authors: Marinelli Et al.
PLoS One 2015;12:244
Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs.
Authors: Lapponi Et al.
J Pharmacol Exp Ther 2013;345:430
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