Ro 106-9920

Catalog # Availability Size / Price Qty
1778/10
1778/50
Cat.No. 1778 - Ro 106-9920 | C10H7N5OS | CAS No. 62645-28-7
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Description: Inhibitor of NF-κB activation

Chemical Name: 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine

Purity: ≥99%

Product Details
Citations (3)
Reviews

Biological Activity

Inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

Technical Data

M.Wt:
245.26
Formula:
C10H7N5OS
Solubility:
Soluble to 5 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
62645-28-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Anticancer agents. XII. Pyridazine and benzodiazine derivatives.
    Conalty et al.
    Proc.R.Ir.Acad.B., 1976;76:151
  2. A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats.
    Swinney et al.
    J.Biol.Chem., 2002;277:23573
  3. Glucocorticoid modulation of MUC5AC secretion in H292 cells.
    Baginski et al.
    Am.Soc.Cell Biol.Abstr., 2002;:765

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Citations for Ro 106-9920

The citations listed below are publications that use Tocris products. Selected citations for Ro 106-9920 include:

3 Citations: Showing 1 - 3

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