Ro 15-4513

Catalog # Availability Size / Price Qty
1997/50
1997/10
Ro 15-4513 | CAS No. 91917-65-6 | Benzodiazepine Inverse Agonists
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Description: Benzodiazepine partial inverse agonist

Chemical Name: 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

High affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.

Technical Data

M.Wt:
326.31
Formula:
C15H14N6O3
Solubility:
Soluble to 5 mM in ethanol and to 10 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
91917-65-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Ro 15-4513

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