Chemical Name: 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
Biological ActivityRo 15-4513 is a high affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A selective imidazobenzodiazepine antagonist of ethanol in the rat.
Suzdak et al.
High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors.
Wong and Skolnick
Pharmacological modulation of the D.pam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2.
Knoflach et al.
Citations for Ro 15-4513
The citations listed below are publications that use Tocris products. Selected citations for Ro 15-4513 include:
2 Citations: Showing 1 - 2
Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice.
Authors: Tracy Et al.
Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment.
Authors: Koh Et al.
J Neurosci 2013;64:145
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Ro 15-4513
There are currently no reviews for this product. Be the first to review Ro 15-4513 and earn rewards!
Have you used Ro 15-4513?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image