Catalog Number: 1997
Chemical Name: 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
Biological Activity
High affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
Technical Data
  • M.Wt:
    326.31
  • Formula:
    C15H14N6O3
  • Solubility:
    Soluble to 5 mM in ethanol and to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    91917-65-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A selective imidazobenzodiazepine antagonist of ethanol in the rat.
    Suzdak et al.
    Science, 1986;234:1243
  2. High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors.
    Wong and Skolnick
    Eur.J.Pharmacol., 1992;225:63
  3. Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2.
    Knoflach et al.
    Mol.Pharmacol., 1996;50:1253
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ro 15-4513 include:

2 Citations: Showing 1 - 2
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  1. Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice.
    Authors: Tracy Et al.
    Psychopharmacology 2016;233:715
  2. Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment.
    Authors: Koh Et al.
    J Neurosci 2013;64:145

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