High affinity benzodiazepine ligand. Ki
values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α
3- and α
receptors. Displays partial agonism at DI α
4- and α
receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
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All Tocris products are intended for laboratory research use only.
A selective imidazobenzodiazepine antagonist of ethanol in the rat.
Suzdak et al.
High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors.
Wong and Skolnick
Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2.
Knoflach et al.
The citations listed below are publications that use Tocris products. Selected citations for Ro 15-4513 include:
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