Chemical Name: 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
Biological ActivityRo 15-4513 is a high affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
A selective imidazobenzodiazepine antagonist of ethanol in the rat.
Suzdak et al.
High affinity ligands for 'D.pam-insensitive' benzodiazepine receptors.
Wong and Skolnick
Pharmacological modulation of the D.pam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2.
Knoflach et al.
Citations for Ro 15-4513
The citations listed below are publications that use Tocris products. Selected citations for Ro 15-4513 include:
2 Citations: Showing 1 - 2
Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice.
Authors: Tracy Et al.
Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment.
Authors: Koh Et al.
J Neurosci 2013;64:145
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