Ro 15-4513

  ( 2 citations )    
Product Datasheet
Catalog Number:1997
Chemical Name:8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
Product Details
Citations (2)
Reviews
Biological Activity
High affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
Technical Data
  • M.Wt:
    326.31
  • Formula:
    C15H14N6O3
  • Solubility:
    Soluble to 5 mM in ethanol and to 10 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    91917-65-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ro 15-4513 include:

2 Citations: Showing 1 - 2
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  1. Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice.
    Authors: Tracy Et al.
    Psychopharmacology  2016;233:715
  2. Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment.
    Authors: Koh Et al.
    J Neurosci  2013;64:145

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