Ro 15-4513

Tocris Bioscience | Catalog # 1997

Benzodiazepine partial inverse agonist
Tocris Bioscience

Key Product Details

Description

Benzodiazepine partial inverse agonist
View all Benzodiazepine Inverse Agonists »

Product Description

Ro 15-4513 is a high affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.

Product Specifications for Ro 15-4513

Molecular Weight

326.31

Formula

C15H14N6O3

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester

CAS Number

91917-65-6

PubChem ID

5081

InChI Key

CFSOJZTUTOQNIA-UHFFFAOYSA-N

SMILES

CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(=C3)N=[N+]=[N-])N2C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.26 10
Ethanol 1.63 5

Preparing Stock Solutions for Ro 15-4513

The following data is based on the product molecular weight 326.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.65 mL 153.23 mL 306.46 mL
0.5 mM 6.13 mL 30.65 mL 61.29 mL
1 mM 3.06 mL 15.32 mL 30.65 mL
5 mM 0.61 mL 3.06 mL 6.13 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 265 publications citing the usage of this product.

Product Documents for Ro 15-4513

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ro 15-4513

For research use only

Customer Reviews for Ro 15-4513

There are currently no reviews for this product. Be the first to review Ro 15-4513 and earn rewards!

Have you used Ro 15-4513?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card