Ro 51

Catalog # Availability Size / Price Qty
4391/10
4391/50
Ro 51 | CAS No. 1050670-85-3 | P2X Receptor Antagonists
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Description: Potent P2X3 and P2X2/3 antagonist

Chemical Name: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-propanediol

Purity: ≥98%

Product Details
Citations (1)
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Reviews

Biological Activity

Potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). Selective for P2X3 and P2X2/3 over other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). Cell permeable.

Technical Data

M.Wt:
474.29
Formula:
C17H23IN4O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1050670-85-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain.
    Jahangir et al.
    Bioorg.Med.Chem.Lett., 2009;19:1632
  2. Pharmacology of P2X receptors
    Syed and Kennedy
    WIREs.Membr.Transp.Signal., 2012;1:16

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Citation for Ro 51

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