Potent, dual P2X3
values are 2 and 5 nM for rP2X3
respectively). Selective for P2X3
over other P2X receptors (IC50
values are > 10 μ
M for P2X1
, and P2X7
). Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain.
Jahangir et al.
Pharmacology of P2X receptors
Syed and Kennedy