Chemical Name: 4,5,6,7-Tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one disodium salt
Biological ActivityRose Bengal is a potent VGlut and vesicular monoamine transporter (VMAT) inhibitor (Ki values are 19 and 64 nM, respectively). Inhibits ATP dependent vesicular glutamate uptake (IC50 = 37 nM) and diminishes the amount of exocytotically released glutamate in synaptosomes. Decreases synaptic transmission in the dentate gyrus. Also stains exposed epithelium in the eye. Cell permeable.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Rose Bengal analogs and vesicular glutamate transporters (VGLUTs).
Pietrancosta et al.
Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal.
Ogita et al.
J Neurochem., 2001;77:34
Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology.
Neale et al.
What is actually stained by rose bengal?
Feenstra et al.
Citation for Rose Bengal
The citations listed below are publications that use Tocris products. Selected citations for Rose Bengal include:
1 Citation: Showing 1 - 1
Perivascular Adipocytes Store Norepinephrine by Vesicular Transport.
Authors: Ahmad Et al.
Arterioscler Thromb Vasc Biol 2019;39:188
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