Rose Bengal (CAS 632-69-9): R&D Systems
Catalog Number: 5168
Chemical Name: 4,5,6,7-Tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one disodium salt
Biological Activity
Potent VGlut and vesicular monoamine transporter (VMAT) inhibitor (Ki values are 19 and 64 nM, respectively). Inhibits ATP dependent vesicular glutamate uptake (IC50 = 37 nM) and diminishes the amount of exocytotically released glutamate in synaptosomes. Decreases synaptic transmission in the dentate gyrus. Also stains exposed epithelium in the eye. Cell permeable.
Technical Data
  • M.Wt:
    1017.64
  • Formula:
    C20H2Cl4I4Na2O5
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    632-69-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Rose Bengal analogs and vesicular glutamate transporters (VGLUTs).
    Pietrancosta et al.
    Bioorg.Med.Chem., 2010;18:6922
  2. Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal.
    Ogita et al.
    J Neurochem., 2001;77:34
  3. Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology.
    Neale et al.
    Neuropsychopharmacology, 2013;38:1060
  4. What is actually stained by rose bengal?
    Feenstra et al.
    Arch.Ophthalmol., 1992;110:984

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