Rose Bengal

Tocris Bioscience | Catalog # 5168

Stains exposed epithelium in eye. Also VGlut and VMAT inhibitor
Tocris Bioscience
Discontinued Product
5168 has been discontinued. View all Glutamate (EAAT) Transporter Inhibitors products.

Key Product Details

Description

Stains exposed epithelium in eye. Also VGlut and VMAT inhibitor
View all Glutamate (EAAT) Transporter Inhibitors »

Product Description

Rose Bengal is a potent VGlut and vesicular monoamine transporter (VMAT) inhibitor (Ki values are 19 and 64 nM, respectively). Inhibits ATP dependent vesicular glutamate uptake (IC50 = 37 nM) and diminishes the amount of exocytotically released glutamate in synaptosomes. Decreases synaptic transmission in the dentate gyrus. Also stains exposed epithelium in the eye. Cell permeable.

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Product Specifications for Rose Bengal

Molecular Weight

1017.64

Formula

C20H2Cl4I4Na2O5

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

4,5,6,7-Tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one disodium salt

CAS Number

632-69-9

PubChem ID

32343

InChI Key

UWBXIFCTIZXXLS-UHFFFAOYSA-L

SMILES

O=C2C(I)=CC(C(OC3=C(I)C(O[Na])=C(I)C=C34)=C2I)=C4C1=C(C(O[Na])=O)C(Cl)=C(Cl)C(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 101.76 100
DMSO 50.88 50

Preparing Stock Solutions for Rose Bengal

The following data is based on the product molecular weight 1017.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.98 mL 4.91 mL 9.83 mL
5 mM 0.20 mL 0.98 mL 1.97 mL
10 mM 0.10 mL 0.49 mL 0.98 mL
50 mM 0.02 mL 0.10 mL 0.20 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for Rose Bengal

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Rose Bengal

For research use only

Customer Reviews for Rose Bengal (1)

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  • works well
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: rat adrenal medulla chromaffin cells
    Verified Customer | Posted 03/29/2020
    100 μM
    Rose Bengal 5168

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