ATPase modulator. Normalizes renal Na+
ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypersensitive rats. Controls mania-like behaviors in Myshkin
mice having a Na+
3 subunit mutation.
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Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.
Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.
Ferrari et al.
Biochim Biophys Acta., 2010;1802:1254
Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump.
Kirshenbaum et al.