Chemical Name: 3β,5β,14β)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol
Biological Activity Na+/K+ ATPase modulator. Inhibits the Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypertensive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ ATPase α3 subunit mutation. Antagonizes the effects of Ouabain (Cat.No. 1076) on myogenic tone and Ca2+ signaling in rat hippocampal neurons.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C
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