Catalog Number: 5315
Alternate Names: PST 2238
Chemical Name: 3β,5β,14β)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol
Biological Activity
Na+/K+ ATPase modulator. Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypersensitive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ ATPase α3 subunit mutation.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.
    Am.J.Physiol.Regul.Integr.Comp.Physiol., 2006;290:529
  2. Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.
    Ferrari et al.
    Biochim Biophys Acta., 2010;1802:1254
  3. Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump.
    Kirshenbaum et al.
    Proc.Natl.Acad.Sci.U.S.A., 2011;108:18144
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