Rostafuroxin
Chemical Name: 3β,5β,14β)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol
Purity: ≥98%
Biological Activity
Rostafuroxin is a Na+/K+ ATPase modulator. Inhibits the Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypertensive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ ATPase α3 subunit mutation. Antagonizes the effects of Ouabain (Cat.No. 1076) on myogenic tone and Ca2+ signaling in rat hippocampal neurons.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.
Ferrari et al.
Biochim Biophys Acta., 2010;1802:1254 -
Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.
Ferrari
Am.J.Physiol.Regul.Integr.Comp.Physiol., 2006;290:529 -
Ouabain-digoxin antagonism in rat arteries and neurones.
Song et al.
J.Physiol., 2014;592:941 -
Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump.
Kirshenbaum et al.
Proc.Natl.Acad.Sci.U.S.A., 2011;108:18144
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