Chemical Name: 3β,5β,14β)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol
Biological ActivityRostafuroxin is a Na+/K+ ATPase modulator. Inhibits the Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypertensive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ ATPase α3 subunit mutation. Antagonizes the effects of Ouabain (Cat.No. 1076) on myogenic tone and Ca2+ signaling in rat hippocampal neurons.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.
Ferrari et al.
Biochim Biophys Acta., 2010;1802:1254
Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.
Ouabain-digoxin antagonism in rat arteries and neurones.
Song et al.
Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump.
Kirshenbaum et al.
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