Rostafuroxin

Key Product Details

Product Description

Rostafuroxin is a Na⁺/K⁺ ATPase modulator. Inhibits the Normalizes renal Na⁺/K⁺ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypertensive rats. Controls mania-like behaviors in Myshkin mice having a Na⁺/K⁺ ATPase α3 subunit mutation. Antagonizes the effects of Ouabain (Cat.No. 1076) on myogenic tone and Ca²⁺ signaling in rat hippocampal neurons.

Product Specifications for Rostafuroxin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Rostafuroxin

The following data is based on the product molecular weight 374.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.35 mL	26.70 mL
5 mM	0.53 mL	2.67 mL	5.34 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Song Ouabain-digoxin antagonism in rat arteries and neurones. J.Physiol. 2014 PMID: 24344167
• Kirshenbaum Mania-like behavior induced by genetic dysfunction of the neuron-specific Na⁺,K⁺-ATPase α3 sodium pump. Proc.Natl.Acad.Sci.U.S.A. 2011 PMID:  22025725
• Ferrari Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. Biochim Biophys Acta. 2010 PMID: 20083196
• Ferrari Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am.J.Physiol.Regul.Integr.Comp.Physiol. 2006 PMID: 16467500

Product Documents for Rostafuroxin