Rottlerin

  ( 4 citations )    
Product Datasheet
Catalog Number:1610
Chemical Name:3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Product Details
Citations (4)
Reviews
Biological Activity
Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 μM respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.
Technical Data
  • M.Wt:
    516.55
  • Formula:
    C30H28O8
  • Solubility:
    Soluble to 2 mM in ethanol with gentle warming and to 20 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    82-08-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Rottlerin include:

4 Citations: Showing 1 - 4
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  1. Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
    Authors: Pietras Et al.
    Nat Cell Biol  2016;18:607
  2. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Bladder (San Franc)  2013;8:e66404
  3. High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival.
    Authors: Barbaric Et al.
    J Biomol Screen  2011;16:603
  4. A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors.
    Authors: Schaertl Et al.
    J Biomol Screen  2010;15:478

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