Biological Activity Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 μM respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.
Soluble to 2 mM in ethanol with gentle warming and to 20 mM in DMSO
Store at +4°C
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For batch specific data refer to the Certificate of Analysis.
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