Rottlerin

Key Product Details

Product Description

Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC₅₀ values are 1.9 and 5 μM respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.

Product Specifications for Rottlerin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Rottlerin

The following data is based on the product molecular weight 516.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.68 mL	48.40 mL	96.80 mL
1 mM	1.94 mL	9.68 mL	19.36 mL
2 mM	0.97 mL	4.84 mL	9.68 mL
10 mM	0.19 mL	0.97 mL	1.94 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 49 publications citing the usage of this product.

• Balgi Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 2009 PMID: 19771169
• Gschwendt Rottlerin, a novel protein kinase inhibitor. Biochem.Biophys.Res.Commun. 1994 PMID: 8123051
• Zhang Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's disease. J.Pharmacol.Exp.Ther. 2007 PMID: 17565007
• Davies Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 2000 PMID: 10998351

Product Documents for Rottlerin