Rottlerin

Catalog # Availability Size / Price Qty
1610/10
1610/50
Rottlerin | CAS No. 82-08-6 | Protein Kinase C Inhibitors
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Description: Reported PKCδ inhibitor

Chemical Name: 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone

Product Details
Citations (6)
Reviews

Biological Activity

Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 μM respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.

Technical Data

M.Wt:
516.55
Formula:
C30H28O8
Solubility:
Soluble to 20 mM in DMSO
Storage:
Store at +4°C
CAS No:
82-08-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Rottlerin

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6 Citations: Showing 1 - 6

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