Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50
values are 1.9 and 5 μ
M respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Davies et al.
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.
Balgi et al.
PLoS One, 2009;4:e7124
Rottlerin, a novel protein kinase inhibitor.
Gschwendt et al.
Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's disease.
Zhang et al.
The citations listed below are publications that use Tocris products. Selected citations for Rottlerin include:
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