RP 67580

Catalog # Availability Size / Price Qty
1635/10
1635/50
RP 67580 | CAS No. 135911-02-3 | NK1 Receptor Antagonists
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Description: Potent and selective NK1 antagonist

Chemical Name: (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol

Purity: ≥97%

Product Details
Citations (4)
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Biological Activity

Potent and selective tachykinin NK1 receptor antagonist (Ki values are 2.9 nM and > 10 μM for rat NK1, and rat NK2 and NK3 receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo, possibly partly via inhibition of calcium channels.

Technical Data

M.Wt:
438.57
Formula:
C29H30N2O2
Solubility:
Soluble to 100 mM in ethanol and to 50 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
135911-02-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for RP 67580

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