Potent and selective tachykinin NK1
receptor antagonist (Ki
values are 2.9 nM and > 10 μ
M for rat NK1
, and rat NK2
receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo
, possibly partly via inhibition of calcium channels.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists.
Beaujouan et al.
Pharmacological properties of a potent and selective nonpeptide substance P antagonist.
Garret et al.
Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.
Fong et al.
Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580.
Rupniak et al.
The citations listed below are publications that use Tocris products. Selected citations for RP 67580 include:
Showing Results 1 - 4 of 4