Rp-8-pCPT-cGMPS sodium

Key Product Details

Product Description

Rp-8-pCPT-cGMPS sodium is a PKG inhibitor (K_i values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro.

Product Specifications for Rp-8-pCPT-cGMPS sodium

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Rp-8-pCPT-cGMPS sodium

The following data is based on the product molecular weight 525.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.90 mL	9.51 mL	19.02 mL
5 mM	0.38 mL	1.90 mL	3.80 mL
10 mM	0.19 mL	0.95 mL	1.90 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Poppe Cyclic nucleotide analogs as probes of signaling pathways. Nat.Methods 2008 PMID: 18376388
• Gamm The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J.Biol.Chem. 1995 PMID: 7593002
• Kim Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca²⁺-permeable AMPA receptors. Proc.Natl.Acad.Sci.U.S.A. 2015 PMID: 25713349

Product Documents for Rp-8-pCPT-cGMPS sodium