Chemical Name: 8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] sodium
Biological ActivityRp-8-pCPT-cGMPS sodium is a PKG inhibitor (Ki values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors.
Kim et al.
Cyclic nucleotide analogs as probes of signaling pathways.
Poppe et al.
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms.
Gamm et al.
Citation for Rp-8-pCPT-cGMPS sodium
The citations listed below are publications that use Tocris products. Selected citations for Rp-8-pCPT-cGMPS sodium include:
1 Citation: Showing 1 - 1
Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system.
Authors: Govindapillai Et al.
Sci Rep 2018;8:6939
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Rp-8-pCPT-cGMPS sodium
There are currently no reviews for this product. Be the first to review Rp-8-pCPT-cGMPS sodium and earn rewards!
Have you used Rp-8-pCPT-cGMPS sodium?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image