PKG inhibitor (Ki
values are 0.45, 0.5 and 0.7 μ
M for PKGIβ
and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro
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Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors.
Kim et al.
Cyclic nucleotide analogs as probes of signaling pathways.
Poppe et al.
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms.
Gamm et al.