RQ 00203078

Catalog # Availability Size / Price Qty
5388/10
5388/50
Cat.No. 5388 - RQ 00203078 | C21H13ClF6N2O5S | CAS No. 1254205-52-1
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Description: Potent and selective TRPM8 antagonist; orally active

Chemical Name: 4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid

Purity: ≥98%

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Biological Activity

Potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). Exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro. Also attenuates icilin-induced wet dog shakes in rats. Orally active.

Technical Data

M.Wt:
554.85
Formula:
C21H13ClF6N2O5S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1254205-52-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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