Chemical Name: (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
Biological Activity(R,R)-THC is a non-steroidal, selective estrogen receptor ligand; agonist at ERα receptor (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β.
Sun et al.
Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-α and estrogen receptor-β: correlations with biological character and distinct differences among SRC coactivator family members.
Kraichely et al.
Citations for (R,R)-THC
The citations listed below are publications that use Tocris products. Selected citations for (R,R)-THC include:
8 Citations: Showing 1 - 8
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system.
Authors: Kola Et al.
PLoS One ;3:e1797
Functional Estrogen Receptors of Red Blood Cells. Do They Influence Intracellular Signaling?
Authors: Vona Et al.
Cell Physiol Biochem 2019;53:186
Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α.
Authors: Wang Et al.
Drug Des Devel Ther 2015;9:3755
Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia.
Authors: Nicholson Et al.
PLoS One 2015;193:722
Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells.
Authors: Li Et al.
Br J Pharmacol 2013;170:489
Estrogen modulates NFκB signaling by enhancing IκBα levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-β.
Authors: Xing Et al.
PLoS One 2012;7:e36890
Src Inhibition with saracatinib reverses fulves. resistance in ER-positive ovarian cancer models in vitro and in vivo.
Authors: Simpkins Et al.
Clin Cancer Res 2012;18:5911
Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.
Authors: Guo Et al.
J Biol Chem 2011;286:27882
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