RS 100329 hydrochloride
Chemical Name: 5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride
Biological ActivityRS 100329 hydrochloride is a subtype-selective α1A-adrenoceptor antagonist (pKi = 9.6 for human cloned α1A receptors). Displays 126- and 50-fold selectivity over human α1B and α1D receptors respectively. Active in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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The role of α1-adrenoceptors and 5-HT1A receptors in the control of the micturition reflex in male anaesthetized rats.
Conley et al.
α1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man.
Shannon Kava et al.
In vitro α1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel α1A-adrenoceptor selective antagonists.
Williams et al.
Citations for RS 100329 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for RS 100329 hydrochloride include:
3 Citations: Showing 1 - 3
Identification of a new pharmacological activity of the phenylpiperazine derivative naftopidil: tubulin-binding drug.
Authors: Ishii and Sugimura
Front Cell Neurosci 2015;8:42618
High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes.
Authors: Zacharia Et al.
PLoS One 2013;8:e65969
Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens.
Authors: Cleary Et al.
Br J Pharmacol 2004;143:745
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