RS 100329 hydrochloride

Key Product Details

Product Description

RS 100329 hydrochloride is a subtype-selective α_1A-adrenoceptor antagonist (pK_i = 9.6 for human cloned α_1A receptors). Displays 126- and 50-fold selectivity over human α_1B and α_1D receptors respectively. Active in vivo.

Licensing Information

Sold with the permission of Roche Bioscience

Product Specifications for RS 100329 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RS 100329 hydrochloride

The following data is based on the product molecular weight 462.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.80 mL	21.60 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Shannon Kava α_1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man. Br.J.Pharmacol. 1998 PMID: 9579731
• Williams In vitro α₁-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel α_1A-adrenoceptor selective antagonists. Br.J.Pharmacol. 1999 PMID: 10369480
• Conley The role of α₁-adrenoceptors and 5-HT_1A receptors in the control of the micturition reflex in male anaesthetized rats. Br.J.Pharmacol. 2001 PMID: 11325795

Product Documents for RS 100329 hydrochloride