Catalog Number: 1325
Chemical Name: 5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride
Biological Activity
Subtype-selective α1A-adrenoceptor antagonist (pKi = 9.6 for human cloned α1A receptors). Displays 126- and 50-fold selectivity over human α1B and α1D receptors respectively. Active in vivo.
Technical Data
  • M.Wt:
    462.89
  • Formula:
    C20H25F3N4O3.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    1215654-26-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Roche Bioscience
Background References
  1. The role of α1-adrenoceptors and 5-HT1A receptors in the control of the micturition reflex in male anaesthetized rats.
    Conley et al.
    Br.J.Pharmacol., 2001;133:61
  2. In vitro α1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel α1A-adrenoceptor selective antagonists.
    Williams et al.
    Br.J.Pharmacol., 1999;127:252
  3. α1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man.
    Shannon Kava et al.
    Br.J.Pharmacol., 1998;123:1359
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RS 100329 hydrochloride include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Identification of a new pharmacological activity of the phenylpiperazine derivative naftopidil: tubulin-binding drug.
    Authors: Ishii and Sugimura
    Front Cell Neurosci 2015;8:42618
  2. High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes.
    Authors: Zacharia Et al.
    PLoS One 2013;8:e65969
  3. Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens.
    Authors: Cleary Et al.
    Br J Pharmacol 2004;143:745

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