RS 102221 hydrochloride

Key Product Details

Product Description

RS 102221 hydrochloride is a potent and selective 5-HT_2C antagonist (pK_i = 8.7). Displays ~ 100-fold selectivity over the 5-HT_2A and 5-HT_2B subtypes and is > 100-fold selective over other 5-HT receptors, α- and β-adrenergic and muscarinic ACh receptors.

Licensing Information

Sold with the permission of Roche Bioscience

Product Specifications for RS 102221 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RS 102221 hydrochloride

The following data is based on the product molecular weight 649.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.54 mL	7.70 mL	15.41 mL
5 mM	0.31 mL	1.54 mL	3.08 mL
10 mM	0.15 mL	0.77 mL	1.54 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Bonhaus Absorption and brain penetration of a high affinity, highly selective 5-HT_2C receptor antagonist, RS-102221. Ann.N.Y.Acad.Sci. 1998 PMID: 9928284
• Weinhardt Some benzenesulphonamido-substituted valerophenones that are selective antagonists for the 5-HT_2C receptor. Bioorg.Med.Chem.Lett.
• Bonhaus RS-102221: a novel high affinity and selective 5-HT_2C receptor antagonist. Neuropharmacology 1997 PMID: 9225287

Product Documents for RS 102221 hydrochloride