RS 39604 hydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:0991
Chemical Name:1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]ethyl]piperidin-4-yl]propan-1-one hydrochloride
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
Technical Data
  • M.Wt:
    590.56
  • Formula:
    C26H36ClN3O6S.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    167710-87-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Roche Bioscience
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RS 39604 hydrochloride include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass.
    Authors: Ratner Et al.
    Learn Mem  2012;20:2133
  2. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One  2009;4:e6453
  3. Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis.
    Authors: Huang and Kandel
    J Pharmacol Exp Ther  2007;14:497

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used RS 39604 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee