Catalog Number: 0991
Chemical Name: 1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]ethyl]piperidin-4-yl]propan-1-one hydrochloride
Biological Activity
A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
Technical Data
  • M.Wt:
    590.56
  • Formula:
    C26H36ClN3O6S.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    167710-87-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Roche Bioscience
Background References
  1. RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist.
    Hegde
    Br.J.Pharmacol., 1995;115:1087
  2. Central 5-HT4 receptors
    Eglen et al.
    TiPS, 1995;16:391
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RS 39604 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass.
    Authors: Ratner Et al.
    Learn Mem 2012;20:2133
  2. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One 2009;4:e6453
  3. Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis.
    Authors: Huang and Kandel
    J Pharmacol Exp Ther 2007;14:497

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