RS 39604 hydrochloride
Chemical Name: 1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]ethyl]piperidin-4-yl]propan-1-one hydrochloride
Biological ActivityRS 39604 hydrochloride is a potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Central 5-HT4 receptors
Eglen et al.
RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist.
Citations for RS 39604 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for RS 39604 hydrochloride include:
3 Citations: Showing 1 - 3
Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass.
Authors: Ratner Et al.
Learn Mem 2012;20:2133
5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
Authors: Müller Et al.
PLoS One 2009;4:e6453
Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis.
Authors: Huang and Kandel
J Pharmacol Exp Ther 2007;14:497
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