RSV Fusion Protein Antibody (RSHZ19 (Felvizumab)) - Chimeric - Azide and BSA Free

Novus Biologicals | Catalog # NBP2-75191

Recombinant Monoclonal Antibody
Novus Biologicals
100% Guarantee

Key Product Details

Species Reactivity

Virus

Applications

ELISA, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # RSHZ19 (Felvizumab)

Format

Azide and BSA Free
View all RSV Fusion Protein Primary Antibodies »

Product Specifications

Immunogen

This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.

Reactivity Notes

Respiratory syncytial virus (RSV)

Specificity

This antibody is specific for the an epitope located between amino acids 417-432 of conserved fusion (F) protein of RSV.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Applications

Application
Recommended Usage

ELISA

1:100 - 1:2000
Application Notes
Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999). This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

0.02% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

Background: RSV Fusion Protein

Alternate Names

Human respiratory syncytial virus, RSV, RSV fusion protein, Rsvgp08, biosimilar antibody, biosimilars

Additional RSV Fusion Protein Products

Product Documents

Certificate of Analysis

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Product Specific Notices

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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