Catalog Number: 1672
Alternate Names: Oxprenoate potassium
Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid, potassium salt
Biological Activity
Potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies.
    Kim et al.
    J.Steroid Biochem.Mol.Biol., 1998;67:213
  2. Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats.
    Rahmouni et al.
    Eur.J.Pharmacol., 1999;385:199
  3. The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro.
    Perroteau et al.
    J.Steroid Biochem., 1984;20:853
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