Potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo
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Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies.
Kim et al.
J.Steroid Biochem.Mol.Biol., 1998;67:213
Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats.
Rahmouni et al.
The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro.
Perroteau et al.
J.Steroid Biochem., 1984;20:853
The citations listed below are publications that use Tocris products. Selected citations for RU 28318, potassium salt include:
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