Catalog Number: 3400
Chemical Name: (bis(2,2'-Bipyridine-N,N')triphenylphosphine)-4-aminobutyric acid ruthenium hexafluorophosphate complex
Biological Activity
Ruthenium-bipyridine-triphenylphosphine caged GABA (Cat. No. 0344) that is excited by visible wavelengths. Provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Produces GABA receptor-mediated currents in pyramidal neurons in vitro and displays no effect on endogenous GABAergic or glutamatergic transmission at concentrations effective for uncaging.
Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under licence from Columbia University
Background References
  1. A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage.
    Zayat et al.
    J.Am.Chem.Soc., 2003;125:882
  2. Photorelease of GABA with visible light using an inorganic caging group.
    Rial Verde et al.
    Front.Neural Circuits, 2008;2:2
Citations:

The citations listed below are publications that use Tocris products. Selected citations for RuBi-GABA include:

1 Citations: Showing 1 - 1

  1. Caged compounds for multichromic optical interrogation of neural systems.
    Authors: Amatrudo Et al.
    Int J Oncol 2015;41:42491

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