Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-(S)-1-aminopropane-1,3-dicarboxylic acid ruthenium(2+) complex sodium hexafluorophosphate salt
Biological ActivityRuthenium-bipyridine-trimethylphosphine caged glutamate that can be excited by visible wavelengths and releases glutamate after one- or two-photon excitation. Has high quantum efficiency and can be used at low concentrations, partly avoiding blockade of GABAergic transmission seen with other caged glutamate compounds. Displays high spatial resolution and generates excitatory responses in individual dendritic spines with physiological kinetics.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
RuBi-Glutamate: two-photon and visible-light photoactivation of neurons and dendritic spines.
Fino et al.
Front.Neural Circuits, 2009;3:1
A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes.
Salierno et al.
Citations for RuBi-Glutamate
The citations listed below are publications that use Tocris products. Selected citations for RuBi-Glutamate include:
5 Citations: Showing 1 - 5
Spike-timing-dependent plasticity rule for single, clustered and distributed dendritic spines.
Authors: Tazerart Et al.
Nat Commun 2020;11:4276
Kilohertz frame-rate two-photon tomography.
Authors: Kazemipour Et al.
Nat Methods 2019;16:778
Probing Single Synapses via the Photolytic Release of Neurotransmitters
Authors: Mitchell Et al.
Front Synaptic Neurosci 2019;11
Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenac.
Authors: Paz Et al.
μ-Opioid Receptor-Mediated Inhibition of Intercalated Neurons and Effect on Synaptic Transmission to the Central Amygdala.
Authors: Blaesse Et al.
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Recording from a DA neuron in the periaqueductal gray. A 6 x 6 grid was used to locally uncage Rubi-glutamate (300 micromolar) in an area surrounding the neuron. Representative trace showing the responses to each focal stimulation in current-clamp mode.