MNI-caged-L-glutamate

  ( 42 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1490
Alternate Names:4-Methoxy-7-nitroindolinyl-caged-L-glutamate, MNI glutamate
Chemical Name:(S)-α-Amino-2,3-dihydro-4-methoxy-7-nitro-δ-oxo-1H-indole-1-pentanoic acid
Product Details
Citations (42)
Reviews
Biological Activity
MNI-caged glutamate that rapidly and efficiently releases glutamate (Cat. No. 0218) when photolysed (300 - 380 nm excitation). Water-soluble, highly resistant to hydrolysis, stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to mM concentrations). 2.5-fold more efficient at releasing L-glutamate than NI-caged L-glutamate.

View more information regarding MNI-caged-L-glutamate.

Technical Data
  • M.Wt:
    323.3
  • Formula:
    C14H17N3O6
  • Solubility:
    Soluble to 50 mM in water with gentle warming
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    295325-62-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the Medical Research Council
Other Product-Specific Information:
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for MNI-caged-L-glutamate include:

42 Citations: Showing 1 - 10
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  1. Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors.
    Authors: Zhang Et al.
    Nat.Commun.  2016;7:12650
  2. A family of photoswitchable NMDA receptors.
    Authors: Berlin Et al.
    Elife  2016;5
  3. The Shaping of Two Distinct Dendritic Spikes by A-Type Voltage-Gated K(+) Channels.
    Authors: Yang Et al.
    J Neurosci  2015;9:469
  4. Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala.
    Authors: Ferreira Et al.
    Nat Commun  2015;9:161
  5. Optical control of NMDA receptors with a diffusible photoswitch.
    Authors: Laprell Et al.
    PLoS One  2015;6:8076
  6. Distribution and function of HCN channels in the apical dendritic tuft of neocortical pyramidal neurons.
    Authors: Harnett Et al.
    PLoS One  2015;35:1024
  7. Melanoma brain colonization involves the emergence of a brain-adaptive phenotype.
    Authors: Nygaard Et al.
    J Neurosci  2015;1:82
  8. The Functional Organization of Neocortical Networks Investigated in Slices with Local Field Recordings and Laser Scanning Photostimulation.
    Authors: Erlandson Et al.
    Front Cell Neurosci  2015;10:e0132008
  9. Fast Decay of CaMKII FRET Sensor Signal in Spines after LTP Induction Is Not Due to Its Dephosphorylation.
    Authors: Otmakhov Et al.
    Front Cell Neurosci  2015;10:e0130457
  10. Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain.
    Authors: Goddard Et al.
    PLoS One  2014;9:e85865
  11. Input integration around the dendritic branches in hippocampal dentate granule cells.
    Authors: Kamijo Et al.
    Cogn Neurodyn  2014;8:267
  12. Adult neurogenesis modifies excitability of the dentate gyrus.
    Authors: Ikrar Et al.
    Front Neural Circuits  2014;7:204
  13. Plasticity of binocularity and visual acuity are differentially limited by nogo receptor.
    Authors: Stephany Et al.
    J Neurosci  2014;34:11631
  14. Directional summation in non-direction selective retinal ganglion cells.
    Authors: Abbas Et al.
    PLoS Comput Biol  2013;9:e1002969
  15. Four-dimensional multi-site photolysis of caged neurotransmitters.
    Authors: Go Et al.
    Front Cell Neurosci  2013;7:231
  16. Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse.
    Authors: Apostolides and Trussell
    J Neurosci  2013;33:4768
  17. Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus.
    Authors: Li Et al.
    Proc Natl Acad Sci U S A  2013;110:9106
  18. Intrinsic connections in the anterior part of the bed nucleus of the stria terminalis.
    Authors: Turesson Et al.
    J Neurophysiol  2013;109:2438
  19. Withdrawal from cocaine self-administration alters NMDA receptor-mediated Ca2+ entry in nucleus accumbens dendritic spines.
    Authors: Ferrario Et al.
    PLoS One  2012;7:e40898
  20. Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue (+)-HIP-B.
    Authors: Callender Et al.
    Biochemistry  2012;51:5486
  21. Alteration of synaptic network dynamics by the intellectual disability protein PAK3.
    Authors: Dubos Et al.
    J Neurosci  2012;32:519
  22. Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy.
    Authors: Zhang Et al.
    J Neurosci  2012;32:1183
  23. Neural circuit mechanisms for pattern detection and feature combination in olfactory cortex.
    Authors: Davison and Ehlers
    Neuron  2011;70:82
  24. Oligodendrocytes as regulators of neuronal networks during early postnatal development.
    Authors: Doretto Et al.
    PLoS One  2011;6:e19849
  25. Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1.
    Authors: Vandenberg Et al.
    Biochem J  2011;439:333
  26. NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination.
    Authors: Biase Et al.
    Oncoscience  2011;31:12650
  27. Hetero-oligomerization of neuronal glutamate transporters.
    Authors: Nothmann Et al.
    J Neurosci  2011;286:3935
  28. Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome.
    Authors: Earls Et al.
    J Biol Chem  2010;30:15843
  29. Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.
    Authors: Tao Et al.
    J Biol Chem  2010;285:17725
  30. Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology.
    Authors: Hammond Et al.
    ACS Chem Neurosci  2010;1:702
  31. High precision and fast functional mapping of cortical circuitry through a novel combination of voltage sensitive dye imaging and laser scanning photostimulation.
    Authors: Xu Et al.
    J Neurophysiol  2010;103:2301
  32. SLM Microscopy: Scanless Two-Photon Imaging and Photostimulation with Spatial Light Modulators.
    Authors: Nikolenko Et al.
    Front Neural Circuits  2009;2:5
  33. Robust short-latency perisomatic inhibition onto neocortical pyramidal cells detected by laser-scanning photostimulation.
    Authors: Brill and Huguenard
    J Neurosci  2009;29:7413
  34. Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency.
    Authors: Wood Et al.
    Proc Natl Acad Sci U S A  2009;29:12440
  35. Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses.
    Authors: Holbro Et al.
    Proc Natl Acad Sci U S A  2009;106:15055
  36. Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit.
    Authors: Brill and Huguenard
    J Reprod Dev  2008;28:13918
  37. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.
    Authors: Shankar Et al.
    J Neurosci  2007;27:2866
  38. Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.
    Authors: Tao Et al.
    J Biol Chem  2006;281:10263
  39. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
    Authors: El-Kouhen Et al.
    Br J Pharmacol  2006;149:761
  40. Dendritic spines linearize the summation of excitatory potentials.
    Authors: Araya Et al.
    Proc Natl Acad Sci U S A  2006;103:18799
  41. The spine neck filters membrane potentials.
    Authors: Araya Et al.
    J Neurosci  2006;103:17961
  42. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
    Authors: Huang Et al.
    J Neurosci  2004;24:4551
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Average Rating: 5 (Based on 1 review)

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Images Ratings Applications Species Reviewed By Date Details
 Glutamate uncaging on dendritic spines 1490 Array 1490
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  Rat Anonymous 10/20/2017
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 Glutamate uncaging on dendritic spines 1490
: Glutamate uncaging on dendritic spines [1490].

Summary

Species Rat
Pub Med ID 23303946

Other Experimental Details

Other Experimental Details We resuspend in ACSF and found that we can freeze and reuse the solution. However, when suspended in HBSS it is no longer effective after freezing.

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