MNI-caged glutamate that rapidly and efficiently releases glutamate
(Cat. No. 0218) when photolysed (300 - 380 nm excitation). Water-soluble, highly resistant to hydrolysis, stable at neutral pH, and pharmacologically inactive at neuronal glutamate receptors (up to mM concentrations). 2.5-fold more efficient at releasing L-glutamate than NI-caged L-glutamate.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from the Medical Research Council
Other Product-Specific Information:
Photochemical and pharmacological evaluation of 7-nitroindolinyl- and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters.
Canepari et al.
Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons.
Matsuzaki et al.
New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups.
Palma-Cerda et al.
Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor.
Maier et al.
Effects of aromatic substitutions on the photocleavage of 1-acyl-7-nitroindolines.
Papageorgiou and Corrie
The citations listed below are publications that use Tocris products. Selected citations for MNI-caged-L-glutamate include:
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