Ruthenium Red

Tocris Bioscience | Catalog # 1439

Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels
Tocris Bioscience

Key Product Details

Description

Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels
View all Cav2.x Channel Blockers »

Product Description

Ruthenium Red blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release.

Product Specifications for Ruthenium Red

Molecular Weight

786.35

Formula

H42N14O2Ru3Cl6

Storage

Store at RT

Chemical Name

Ammoniated ruthenium oxychloride

CAS Number

11103-72-3

PubChem ID

16218584

InChI Key

JQJSTVUROJELSR-UHFFFAOYSA-H

SMILES

[Ru+2]O[Ru+2]O[Ru+2].N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.86 10

Preparing Stock Solutions for Ruthenium Red

The following data is based on the product molecular weight 786.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.72 mL 63.58 mL 127.17 mL
0.5 mM 2.54 mL 12.72 mL 25.43 mL
1 mM 1.27 mL 6.36 mL 12.72 mL
5 mM 0.25 mL 1.27 mL 2.54 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 104 publications citing the usage of this product.

Product Documents for Ruthenium Red

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ruthenium Red

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Ruthenium Red (1)

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  • Ruthenium red blocks RyR2-mediated oscillations in HEK293 cells.
    Name: Niroj Shrestha
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK293
    Verified Customer | Posted 07/27/2019
    HEK293 cells, stably expressing RyR2 receptors, were loaded with intracellular Ca2+ sensitive dye, Fura2AM and excited alternately at 340 and 380 nm and fluorescence at 510 nm was expressed as 340/380 ratio. These cells elicit store-overload induced Ca2+ release (cytosolic oscillations) via RyR2 in presence of 2 mM extracellular Ca2+. 10 μM ruthenium red blocks RyR2 and subsequent Ca2+ release and oscillations in these cells.
    Ruthenium Red 1439

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