uptake and release from mitochondria, and Ca2+
release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50
= 14 nM) and voltage-sensitive Ca2+
channels to inhibit neurotransmitter release.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Ruthenium red as a capsaicin antagonist.
Amann and Maggi
Life Sci., 1991;49:849
Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red.
Bernardi et al.
Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) by multiple mechanisms.
Xu et al.
Vanilloid (capsaicin) receptors and mechanisms.
Szallasi and Blumberg
The citations listed below are publications that use Tocris products. Selected citations for Ruthenium Red include:
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