Catalog Number: 1439
Chemical Name: Ammoniated ruthenium oxychloride
Biological Activity
Blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release.
Technical Data
  • M.Wt:
    786.35
  • Formula:
    H42N14O2Ru3Cl6
  • Solubility:
    Soluble to 10 mM in water
  • Storage:
    Store at RT
  • CAS No:
    11103-72-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ruthenium red as a capsaicin antagonist.
    Amann and Maggi
    Life Sci., 1991;49:849
  2. Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red.
    Bernardi et al.
    Biochemistry, 1984;23:1645
  3. Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) by multiple mechanisms.
    Xu et al.
    J.Biol.Chem., 1999;274:32680
  4. Vanilloid (capsaicin) receptors and mechanisms.
    Szallasi and Blumberg
    Pharmacol.Rev., 1999;51:159
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ruthenium Red include:

10 Citations: Showing 1 - 10
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  1. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides.
    Authors: Ferdek Et al.
    Cell.Death.Dis. 2017;8
  2. Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
    Authors: Russo Et al.
    The Journal of Immunology 2016;197:1353
  3. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
    Authors: Shi Et al.
    Proc Natl Acad Sci U S A 2015;21:4852
  4. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol.
    Authors: Merino Et al.
    Neuroreport 2015;10:e0132884
  5. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
    Authors: Lee Et al.
    PLoS One 2014;111:E5114
  6. Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels.
    Authors: Nesuashvili Et al.
    Mol Pharmacol 2013;83:1007
  7. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.
    Authors: Kaszás Et al.
    J Neurosci 2012;340:152
  8. TRPV4 channels mediate the infrared laser-evoked response in sensory neurons.
    Authors: Albert Et al.
    J Neurophysiol 2012;107:3227
  9. Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores.
    Authors: Jacques-Fricke Et al.
    World J Gastroenterol 2006;26:5656
  10. Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation.
    Authors: Moran Et al.
    J Neurophysiol 2004;92:3266

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