Chemical Name: Ammoniated ruthenium oxychloride
Biological ActivityBlocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red.
Bernardi et al.
Ruthenium red as a capsaicin antagonist.
Amann and Maggi
Life Sci., 1991;49:849
Vanilloid (capsaicin) receptors and mechanisms.
Szallasi and Blumberg
Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) by multiple mechanisms.
Xu et al.
Citations for Ruthenium Red
The citations listed below are publications that use Tocris products. Selected citations for Ruthenium Red include:
18 Citations: Showing 1 - 10
High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
Authors: Battefeld Et al.
Cell Rep 2019;26:182
Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease.
Redox Biol 2018;19:290
Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons.
Authors: Fernandez-Fernandez Et al.
PLoS One 2018;13:e0199282
BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides.
Authors: Ferdek Et al.
Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
Authors: Russo Et al.
The Journal of Immunology 2016;197:1353
Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells.
Authors: Son Et al.
J Dent Res 2015;94:473
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
Authors: Shi Et al.
Proc Natl Acad Sci U S A 2015;21:4852
Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote.
Authors: Merino Et al.
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
Authors: Lee Et al.
PLoS One 2014;111:E5114
Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels.
Authors: Nesuashvili Et al.
Mol Pharmacol 2013;83:1007
Rapid Glucocorticoid-Induced Activation of TRP and CB1 Receptors Causes Biphasic Modulation of Glutamate Release in Gastric-Related Hypothalamic Preautonomic Neurons.
Authors: Boychuk Et al.
Front Neurosci 2013;7:3
Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.
Authors: Kaszás Et al.
J Neurosci 2012;340:152
TRPV4 channels mediate the infrared laser-evoked response in sensory neurons.
Authors: Albert Et al.
J Neurophysiol 2012;107:3227
TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.
Authors: Li Et al.
Environ Health Perspect 2011;119:784
Glutathione levels modulate domoic acid induced apoptosis in mouse cerebellar granule cells.
Authors: Giordano Et al.
Toxicol Sci 2007;100:433
Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores.
Authors: Jacques-Fricke Et al.
World J Gastroenterol 2006;26:5656
Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation.
Authors: Moran Et al.
J Neurophysiol 2004;92:3266
Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in DA neurons.
Authors: Melis Et al.
J Neurosci 2004;24:10707
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Reviews for Ruthenium Red
Average Rating: 4 (Based on 1 Review)
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HEK293 cells, stably expressing RyR2 receptors, were loaded with intracellular Ca2+ sensitive dye, Fura2AM and excited alternately at 340 and 380 nm and fluorescence at 510 nm was expressed as 340/380 ratio. These cells elicit store-overload induced Ca2+ release (cytosolic oscillations) via RyR2 in presence of 2 mM extracellular Ca2+. 10 μM ruthenium red blocks RyR2 and subsequent Ca2+ release and oscillations in these cells.