Ruthenium Red

Catalog # Availability Size / Price Qty
Ruthenium Red | CAS No. 11103-72-3 | Cav2.x Channel Blockers
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Description: Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels

Chemical Name: Ammoniated ruthenium oxychloride

Product Details
Citations (18)

Biological Activity

Ruthenium Red blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release.

Technical Data

Soluble to 10 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Commensal Bacteria-Induced Inflammasome Activation in Mouse and Human Macrophages Is Dependent on Potassium Efflux but Does Not Require Phagocytosis or Bacterial Viability

    PLoS ONE, 2016;11(8):e0160937.
  2. Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging.
    Sauvant J, Delpech J, Palin K, De Mota N, Dudit J, Aubert A, Orcel H, Roux P, Laye S, Moos F, Llorens-Cortes C, Nadjar A
    PLoS ONE, 2014;9(2):e87421.
  3. Activation of NLRP3 inflammasome by crystalline structures via cell surface contact.
    Hari A, Zhang Y, Tu Z, Detampel P, Stenner M, Ganguly A, Shi Y
    Sci Rep, 2014;4(0):7281.
  4. Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red.
    Bernardi et al.
    Biochemistry, 1984;23:1645
  5. Ruthenium red as a capsaicin antagonist.
    Amann and Maggi
    Life Sci., 1991;49:849
  6. Vanilloid (capsaicin) receptors and mechanisms.
    Szallasi and Blumberg
    Pharmacol.Rev., 1999;51:159
  7. Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) by multiple mechanisms.
    Xu et al.
    J.Biol.Chem., 1999;274:32680

Product Datasheets

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Citations for Ruthenium Red

The citations listed below are publications that use Tocris products. Selected citations for Ruthenium Red include:

18 Citations: Showing 1 - 10

  1. High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
    Authors: Battefeld Et al.
    Cell Rep  2019;26:182
  2. Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease.
    Authors: P?rez
    Redox Biol  2018;19:290
  3. Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons.
    Authors: Fernandez-Fernandez Et al.
    PLoS One  2018;13:e0199282
  4. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides.
    Authors: Ferdek Et al.
    Cell.Death.Dis.  2017;8:e2640
  5. Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
    Authors: Russo Et al.
    The Journal of Immunology  2016;197:1353
  6. Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells.
    Authors: Son Et al.
    J Dent Res  2015;94:473
  7. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
    Authors: Shi Et al.
    Proc Natl Acad Sci U S A  2015;21:4852
  8. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote.
    Authors: Merino Et al.
    Neuroreport  2015;10:e0132884
  9. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
    Authors: Lee Et al.
    PLoS One  2014;111:E5114
  10. Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels.
    Authors: Nesuashvili Et al.
    Mol Pharmacol  2013;83:1007


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