Biological Activity Selective p38α and p38β inhibitor (IC50 values are 1 and 11 μM respectively) that displays no activity at p38γ, p38δ and a range of other kinases. Potently inhibits TNF-α and IL-1β release (IC50 values are 3 and 11 nM respectively) and suppresses HIV-1 replication in T cells in vitro. Displays cardioprotective and anti-inflammatory activity in vivo. Orally active.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at RT
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For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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