hh RX 821002 hydrochloride (CAS 109544-45-8): R&D Systems
Catalog Number: 1324
Chemical Name: 2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
Biological Activity
Potent, selective α2-adrenoceptor antagonist with very low affinity for imidazoline sites. Displays selectivity for the α2D over the α2A subtypes (pKd values are 9.7 and 8.2 respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Does [3H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [3H]rauwolscine? A comparison of nine tissues and cell lines.
    Erdbrugger et al.
    J.Pharmacol.Exp.Ther., 1995;273:1287
  2. Characterisation of [3H]RX 821002 binding to alpha-2 adrenergic receptor subtypes.
    O'Rourke et al.
    J.Pharmacol.Exp.Ther., 1994;268:1362
  3. Antagonists that differentiate between α2A- and α2D-adrenoceptors.
    Trendelenburg et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1996;353:245

The citations listed below are publications that use Tocris products. Selected citations for RX 821002 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats.
    Authors: Alves Et al.
    J Chem Biol 2014;9:e83900
  2. Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear.
    Authors: Hott Et al.
    Br J Pharmacol 2012;167:207
  3. Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats.
    Authors: Crestani Et al.
    Br J Pharmacol 2008;153:583

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