RX 821002 hydrochloride

Key Product Details

Product Description

RX 821002 hydrochloride is a potent, selective α₂-adrenoceptor antagonist with very low affinity for imidazoline sites. Displays selectivity for the α_2D over the α_2A subtypes (pK_d values are 9.7 and 8.2 respectively).

Product Specifications for RX 821002 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RX 821002 hydrochloride

The following data is based on the product molecular weight 270.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.47 mL	36.94 mL
5 mM	0.74 mL	3.69 mL	7.39 mL
10 mM	0.37 mL	1.85 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• O'Rourke Characterisation of [³H]RX 821002 binding to alpha-2 adrenergic receptor subtypes. J.Pharmacol.Exp.Ther. 1994 PMID: 7908054
• Trendelenburg Antagonists that differentiate between α_2A- and α_2D-adrenoceptors. Naunyn Schmiedebergs Arch.Pharmacol. 1996 PMID: 8692278
• Erdbrugger Does [³H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [³H]rauwolscine? A comparison of nine tissues and cell lines. J.Pharmacol.Exp.Ther. 1995 PMID: 7791100

Product Documents for RX 821002 hydrochloride