Ryanodine Receptor 2 Antibody - BSA Free

Novus Biologicals | Catalog # NBP3-45456

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry, Western Blot, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Ryanodine Receptor 2 Primary Antibodies »

Product Specifications

Immunogen

ryanodine receptor 2(cardiac). (Uniprot# Q92736)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

250 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Ryanodine Receptor 2 Antibody - BSA Free

Ryanodine Receptor 2 Antibody - BSA Free

Western Blot: Ryanodine Receptor 2 Antibody - BSA Free [NBP3-45456] -

Western Blot: Ryanodine Receptor 2 Antibody - BSA Free [NBP3-45456] - HeLa cells were subjected to SDS PAGE followed by western blot with (Ryanodine Receptor 2 antibody) at dilution of 1:500
Ryanodine Receptor 2 Antibody - BSA Free

Immunohistochemistry: Ryanodine Receptor 2 Antibody - BSA Free [NBP3-45456] -

Immunohistochemistry: Ryanodine Receptor 2 Antibody - BSA Free [NBP3-45456] - Immunohistochemistry of paraffin-embedded human heart tissue slide using (Ryanodine Receptor 2 Antibody) at dilution of 1:200

Applications for Ryanodine Receptor 2 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:100-1:400

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 50% Glycerol, pH (7.3)

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Ryanodine Receptor 2

Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca2+ from internal stores. The alpha1-subunit of the DHPR contains a cytoplasmic loop which is thought to be involved in the interactions with RyR. Phosphorylation of the DHPR alpha1-subunit is also thought to play a role in the functional interaction of DHPR and RyR. Mutation in DHPR alpha1 results in excitation-contraction uncoupling, leading to muscular dysgenesis, a complete inactivity in developing skeletal muscles. Cells that do not express RyR also lack excitation-contraction coupling and exhibit a severalfold reduction in Ca2+ current density.

Long Name

Ryanodine receptor 2

Alternate Names

hRYR-2, RYR-2, RyR2

Gene Symbol

RYR2

Additional Ryanodine Receptor 2 Products

Product Documents for Ryanodine Receptor 2 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Ryanodine Receptor 2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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