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S 18986

3911 Datasheet / COA / SDS
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3911/10
3911/50
S 18986 | CAS No. 175340-20-2 | AMPA Receptor Modulators
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Description: Positive allosteric modulator of AMPA receptors

Chemical Name: (3aS)-2,3,3a,4-Tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine-5,5-dioxide

Purity: ≥98%

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Biological Activity

Positive allosteric modulator of AMPA receptors. Exhibits cognitive enhancing properties in rodent behavioral models. Brain penetrant.

Technical Data

M.Wt:
224.28
Formula:
C10H12N2O2S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
175340-20-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Enantioselective synthesis of a pyrrolo-benzothiadiazine derivative S 18986, a new AMPA receptor positive modulator.
    Desos et al.
    Bioorg.Med.Chem.Lett., 1996;6:3003
  2. (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices.
    Lockhart et al.
    Eur.J.Pharmacol., 2000;401:145
  3. Neuropharmacokinetics of a new α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat.
    Bourasset et al.
    Drug Metab.Dispos., 2005;33:1137

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