Potent, selective mGlu8a
= 31 nM). Displays > 100-fold selectivity over mGlu1-7
and displays little or no activity at NMDA and kainate receptors. Increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo
. Also potent anticonvulsant in mice in vivo
. Caged (S)-3,4-DCPG
(Cat. No. 3330), (RS)-3,4-DCPG
(Cat. No. 1394) and (R)-3,4-DCPG
(Cat. No. 1395) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice.
Moldrich et al.
Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice.
Linden et al.
Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones.
Thomas et al.
(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
Thomas et al.
The citations listed below are publications that use Tocris products. Selected citations for (S)-3,4-DCPG include:
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