Chemical Name: (S)-3,4-Dicarboxyphenylglycine
Biological ActivityPotent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu1-7 and displays little or no activity at NMDA and kainate receptors. Increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Also potent anticonvulsant in mice in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice.
Linden et al.
Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice.
Moldrich et al.
Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones.
Thomas et al.
(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
Thomas et al.
Citation for (S)-3,4-DCPG
The citations listed below are publications that use Tocris products. Selected citations for (S)-3,4-DCPG include:
1 Citation: Showing 1 - 1
Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata.
Authors: Broadstock Et al.
Br J Pharmacol 2012;165:1034
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