Catalog Number: 1302
Alternate Names: UBP 1109
Chemical Name: (S)-3,4-Dicarboxyphenylglycine
Biological Activity
Potent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu1-7 and displays little or no activity at NMDA and kainate receptors. Increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Also potent anticonvulsant in mice in vivo. Caged (S)-3,4-DCPG (Cat. No. 3330), (RS)-3,4-DCPG (Cat. No. 1394) and (R)-3,4-DCPG (Cat. No. 1395) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice.
    Moldrich et al.
    Neuropharmacology, 2001;40:732
  2. Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice.
    Linden et al.
    Neuropharmacology, 2003;45:473
  3. Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones.
    Thomas et al.
    Eur.J.Pharmacol., 1997;338:111
  4. (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
    Thomas et al.
    Neuropharmacology, 2001;40:311

The citations listed below are publications that use Tocris products. Selected citations for (S)-3,4-DCPG include:

Showing Results 1 - 1 of 1

  1. Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata.
    Authors: Broadstock Et al.
    Br J Pharmacol
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