Catalog Number: 0320
Alternate Names: (S)-4C3HPG
Biological Activity
Competitive antagonist at group I mGlu1a/1a receptors, mixed effect at mGlu5a/5b receptors; agonist at group II metabotropic glutamate receptors. (RS)-4-Carboxy-3-hydroxyphenylglycine (Cat. No. 0310) also available.
Technical Data
  • M.Wt:
    211.17
  • Formula:
    C9H9NO5
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 5 mM in water
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    85148-82-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.
    Sekiyama et al.
    Br. J. Pharmacol., 1996;117:1493
  2. Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects mGluR1α and mGluR5a subtypes.
    Kingston et al.
    Neuropharmacology, 1995;34:887
  3. Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system
    Birse et al.
    Neuroscience, 1993;52:481
  4. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types.
    Hayashi et al.
    J.Neurosci., 1994;14:3370
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (S)-4-Carboxy-3-hydroxyphenylglycine include:

1 Citations: Showing 1 - 1

  1. Inhibition and enhancement of contextual fear memory destabilization.
    Authors: Lee and Flavell
    Front Behav Neurosci 2014;8:144

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