(S)-4-Carboxy-3-hydroxyphenylglycine

Key Product Details

Product Description

(S)-4-Carboxy-3-hydroxyphenylglycine is a competitive antagonist at group I mGlu_1a/1a receptors, mixed effect at mGlu_5a/5b receptors; agonist at group II metabotropic glutamate receptors.

Racemate also available.

Product Specifications for (S)-4-Carboxy-3-hydroxyphenylglycine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (S)-4-Carboxy-3-hydroxyphenylglycine

The following data is based on the product molecular weight 211.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

14 13 12 11 10 9 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.74 mL	23.68 mL	47.36 mL
5 mM	0.95 mL	4.74 mL	9.47 mL
10 mM	0.47 mL	2.37 mL	4.74 mL
50 mM	0.09 mL	0.47 mL	0.95 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sekiyama Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 1996 PMID: 8730745
• Hayashi Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types. J.Neurosci. 1994 PMID: 8182479
• Kingston Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects mGluR1α and mGluR5a subtypes. Neuropharmacology 1995 PMID: 8532170
• Birse Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system Neuroscience 1993 PMID: 7680790

Product Documents for (S)-4-Carboxy-3-hydroxyphenylglycine