Catalog Number: 6025
Chemical Name: 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
Biological Activity
Potent MTH1 inhibitor (IC50 = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro. Suppresses tumor growth ~50% in a colon cancer carcinoma xenograft model.
Technical Data
  • M.Wt:
    450.34
  • Formula:
    C21H22Cl2FN5O
  • Solubility:
    Soluble to 50 mM in DMSO and to 20 mM in 1eq. HCl with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    1374356-45-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc
Background References
  1. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
    Huber et al.
    Nature, 2014;508:222
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