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(S)-Duloxetine hydrochloride

4798 1 Citation Datasheet / COA / SDS
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4798/50
Cat.No. 4798 - (S)-Duloxetine hydrochloride | C18H19NOS.HCl | CAS No. 136434-34-9
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Description: Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake

Chemical Name: (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

Technical Data

M.Wt:
333.88
Formula:
C18H19NOS.HCl
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
136434-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for (S)-Duloxetine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for (S)-Duloxetine hydrochloride include:

1 Citation: Showing 1 - 1

  1. Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.
    Authors: Skelly and Weiner
    Brain Behav  2014;4:468

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VersaClone cDNA Plasmids

Human SLC6A2/NET (NP_001165975) VersaClone cDNA

RDC1141

Human SLC6A2/NET (NP_001034) VersaClone cDNA

RDC1112

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