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Catalog Number:4798
Chemical Name:(+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.
High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.
Technical Data
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M.Wt:333.88
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Formula:C18H19NOS.HCl
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Solubility:Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
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Purity:>99
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Storage:Store at RT
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CAS No:136434-34-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:
The citations listed below are publications that use Tocris products. Selected citations for (S)-Duloxetine hydrochloride include:
1 Citations: Showing 1 - 1
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