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(S)-Duloxetine hydrochloride

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(S)-Duloxetine hydrochloride | CAS No. 136434-34-9 | 5-HT Transporter Inhibitors
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Description: Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake

Chemical Name: (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

(S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

Technical Data

M.Wt:
333.88
Formula:
C18H19NOS.HCl
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
136434-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for (S)-Duloxetine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for (S)-Duloxetine hydrochloride include:

1 Citation: Showing 1 - 1

  1. Chronic treatment with pra. or dulox. lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.
    Authors: Skelly and Weiner
    Brain Behav  2014;4:468

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VersaClone cDNA Plasmids

Human SLC6A2/NET (NP_001034) VersaClone cDNA

RDC1112

Human SLC6A2/NET (NP_001165975) VersaClone cDNA

RDC1141

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