Chemical Name: (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride
Biological Activity(S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
LY227942, an inhibitor of serotonin and NE uptake: biochemical pharmacology of a potential antidepressant drug.
Wong et al.
Life Sci., 1988;43:2049
Blockade of the serotonin and NE uptake processes by duloxetine: in vitro and in vivo studies in the rat brain.
Kasamo et al.
Citations for (S)-Duloxetine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for (S)-Duloxetine hydrochloride include:
4 Citations: Showing 1 - 4
Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice.
Authors: Melitta Et al.
Int J Mol Sci 2022;23
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.
Authors: Henry A Et al.
Effect of monoamine reuptake inhibition and α1 blockade on respiratory arrest and death following electroshock-induced seizures in mice.
Authors: Gordon F Et al.
Chronic treatment with pra. or dulox. lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.
Authors: Skelly and Weiner
Brain Behav 2014;4:468
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