(S)-Duloxetine hydrochloride

Key Product Details

Product Description

(S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (K_i values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC₅₀ values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (K_i = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

Product Specifications for (S)-Duloxetine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (S)-Duloxetine hydrochloride

The following data is based on the product molecular weight 333.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.00 mL	14.98 mL	29.95 mL
5 mM	0.60 mL	3.00 mL	5.99 mL
10 mM	0.30 mL	1.50 mL	3.00 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Kasamo Blockade of the serotonin and NE uptake processes by duloxetine: in vitro and in vivo studies in the rat brain. J.Pharmacol.Exp.Ther. 1996 PMID: 8613930
• Wong LY227942, an inhibitor of serotonin and NE uptake: biochemical pharmacology of a potential antidepressant drug. Life Sci. 1988 PMID: 2850421

Product Documents for (S)-Duloxetine hydrochloride