(S)-(-)-5-Iodowillardiine

Key Product Details

Product Description

Demonstrates high affinity for the kainate receptor subtype hGluK1 (formerly hGluR5) (K_i = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluK2 (formerly hGluR6).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for (S)-(-)-5-Iodowillardiine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (S)-(-)-5-Iodowillardiine

The following data is based on the product molecular weight 325.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	12.31 mL	61.53 mL	123.05 mL
1.25 mM	2.46 mL	12.31 mL	24.61 mL
2.5 mM	1.23 mL	6.15 mL	12.31 mL
12.5 mM	0.25 mL	1.23 mL	2.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Thompson Depolarising effects of certain derivatives of (S) willardiine upon in vitro neonatal rat dorsal roots. Br.J.Pharmacol.
• Wong Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones. J.Neurosci. 1994 PMID: 7515954
• Patneau Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 1992 PMID: 1371315
• Swanson Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. Mol.Pharmacol. 1998 PMID: 9584222
• Jane Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J.Med.Chem. 1997 PMID: 9357531

Product Documents for (S)-(-)-5-Iodowillardiine