(S)-(-)-Blebbistatin

Tocris Bioscience | Catalog # 1852

Selective inhibitor of myosin II ATPase activity. Active enantiomer of (±)-blebbistatin (Cat. No. 1760)
Tocris Bioscience

Key Product Details

Description

Selective inhibitor of myosin II ATPase activity. Active enantiomer of (±)-blebbistatin (Cat. No. 1760)
View all Myosin Inhibitors »

Product Description

(S)-(-)-Blebbistatin is a selective inhibitor of myosin II ATPase activity (IC50 ~0.5 - 5 μM); active enantiomer of (±)-blebbistatin. Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (S)-(-)-Blebbistatin rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.

Inactive Enantiomer and Racemate also available.

Product Specifications for (S)-(-)-Blebbistatin

Molecular Weight

292.34

Formula

C18H16N2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(3aS)-(-)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one

CAS Number

856925-71-8

PubChem ID

5287792

InChI Key

LZAXPYOBKSJSEX-GOSISDBHSA-N

SMILES

O=C2[C@@]3(O)C(N(C4=CC=CC=C4)CC3)=NC1=CC=C(C)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.23 100

Preparing Stock Solutions for (S)-(-)-Blebbistatin

The following data is based on the product molecular weight 292.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.10 mL 34.21 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

Product Documents for (S)-(-)-Blebbistatin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (S)-(-)-Blebbistatin

For research use only

Citations for (S)-(-)-Blebbistatin

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