Negative control of (R)-PFI 2 hydrochloride
(Cat. No. 4892). Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC50
= 1 μ
M) compared to the active enantiomer.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (R)-PFI 2 probe summary
on the SGC website.
Other Product-Specific Information:
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Barsyte-Lovejoy et al.
Proc.Natl.Acad.Sci.U S A, 2014;111:12853