(R)-PFI 2 hydrochloride

Tocris Bioscience | Catalog # 4892

Potent and selective SETD7 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective SETD7 inhibitor
View all Lysine Methyltransferase Inhibitors »

Product Description

(R)-PFI 2 hydrochloride is a potent and selective SETD7 histone lysine methyltransferase inhibitor (IC50 = 2 nM). Exhibits >1000-fold selectivity over DNMT1 and a panel of 18 other methyltransferases. Inhibits YAP nuclear translocation and function following activation of the Hippo signaling pathway in MCF7 cells.

Negative Control also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (R)-PFI 2 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of (R)-PFI 2 is reviewed on the chemical probes website.

Product Specifications for (R)-PFI 2 hydrochloride

Molecular Weight

535.98

Formula

C23H25F4N3O3S.HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride

CAS Number

1627607-87-7

PubChem ID

78243738

InChI Key

ZADKZNVAJGEFLC-ZMBIFBSDSA-N

SMILES

O=C(N4CCCC4)[C@@H](CC3=CC=CC(C(F)(F)F)=C3)NS(C2=CC1=C(C(F)=C2)CNCC1)(=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.6 100
Ethanol 10.72 20 with sonication

Preparing Stock Solutions for (R)-PFI 2 hydrochloride

The following data is based on the product molecular weight 535.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.33 mL 18.66 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for (R)-PFI 2 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (R)-PFI 2 hydrochloride

For research use only

Related Research Areas

Epigenetics

Citations for (R)-PFI 2 hydrochloride

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