Potent and selective SETD7 histone lysine methyltransferase inhibitor (IC50
= 2 nM). Exhibits >1000-fold selectivity over DNMT1 and a panel of 18 other methyltransferases. Inhibits YAP nuclear translocation and function following activation of the Hippo signaling pathway in MCF7 cells. Negative control (S)-PFI 2 hydrochloride
(Cat. No. 5400) available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (R)-PFI 2 probe summary
on the SGC website.
Other Product-Specific Information:
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Barsyte-Lovejoy et al.
Proc.Natl.Acad.Sci.U S A, 2014;111:12853
The citations listed below are publications that use Tocris products. Selected citations for (R)-PFI 2 hydrochloride include:
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