Catalog Number: 1561
Chemical Name: 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid
Biological Activity
GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo.
Technical Data
  • M.Wt:
    505.61
  • Formula:
    C30H35NO6
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    157604-55-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site.
    Borden et al.
    Receptors Channels, 1994;2:207
  2. GABA transporter heterogeneity: pharmacology and cellular localization.
    Borden
    Neurochem.Int., 1996;29:335
  3. GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.
    Dalby
    Neuropharmacology, 2000;39:2399
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (S)-SNAP 5114 include:

4 Citations: Showing 1 - 4
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  1. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Physiol 2016;36:607
  2. Recurrent seizure-like events are associated with coupled astroglial synchronization.
    Authors: Kékesi Et al.
    J Neurosci 2015;9:215
  3. A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus.
    Authors: Kersanté Et al.
    J Neurophysiol 2013;591:2429
  4. GAT-3 transporters regulate inhibition in the neocortex.
    Authors: Kinney
    Mol Pain 2005;94:4533

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