GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50
values are 5, 21 and 388 μ
M for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site.
Borden et al.
Receptors Channels, 1994;2:207
GABA transporter heterogeneity: pharmacology and cellular localization.
GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.
The citations listed below are publications that use Tocris products. Selected citations for (S)-SNAP 5114 include:
Showing Results 1 - 4 of 4