Catalog Number: 1253
Chemical Name: (S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride
Biological Activity
Potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM). Centrally active on systemic administration.
Technical Data
  • M.Wt:
    468.47
  • Formula:
    C24H33N3O2.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming and to 10 mM in water with sonica
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    149007-54-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Wyeth-Ayerst Research, US Patent 4,988,814
Background References
  1. WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.
    Fletcher et al.
    Eur.J.Pharmacol., 1993;237:283
  2. Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents.
    Fletcher et al.
    Trends Pharmacol.Sci., 1993;14:41
  3. (S)-N-tert-Butyl-3(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.
    Cliffe et al.
    J.Med.Chem., 1993;36:1509
  4. Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test.
    Rodgers and Cole
    Eur.J.Pharmacol., 1994;261:321
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (S)-WAY 100135 dihydrochloride include:

3 Citations: Showing 1 - 3
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  1. The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.
    Authors: Borroto-Escuela Et al.
    J Neurosci 2012;32:6295
  2. 5-HT1A receptor-responsive pedunculopontine tegmental neurons suppress REM sleep and respiratory motor activity.
    Authors: Grace Et al.
    J Neurosci 2012;32:1622
  3. 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum.
    Authors: Foong Et al.
    J Neurosci 2010;298:G384

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