(S)-WAY 100135 dihydrochloride

  ( 5 citations )    
Product Datasheet
Catalog Number:1253
Chemical Name:(S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride
Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity
Potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM). Centrally active on systemic administration.
Technical Data
  • M.Wt:
    468.47
  • Formula:
    C24H33N3O2.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming and to 10 mM in water with sonica
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    149007-54-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Wyeth-Ayerst Research, US Patent 4,988,814
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (S)-WAY 100135 dihydrochloride include:

5 Citations: Showing 1 - 5
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  1. Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT?a receptor antagonist.
    Authors: Pandya and Yakel
    Neuropharmacology  2013;70:35
  2. The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.
    Authors: Borroto-Escuela Et al.
    J Neurosci  2012;32:6295
  3. 5-HT1A receptor-responsive pedunculopontine tegmental neurons suppress REM sleep and respiratory motor activity.
    Authors: Grace Et al.
    J Neurosci  2012;32:1622
  4. Multiple neural oscillators and muscle feedback are required for the intestinal fed state motor program.
    Authors: Chambers Et al.
    PLoS One  2011;6:e19597
  5. 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum.
    Authors: Foong Et al.
    J Neurosci  2010;298:G384

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VersaClone cDNA Plasmids
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Human 5-HT1A (NP_000515) VersaClone cDNA

RDC0283
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