(S)-WAY 100135 dihydrochloride

Key Product Details

Product Description

(S)-WAY 100135 dihydrochloride is a potent, selective 5-HT_1A receptor antagonist (IC₅₀ = 15 nM). Selective over 5-HT_1B, _1C, ₂,α₁, α₂ and D₂ receptors (IC₅₀ > 1000 nM). Centrally active on systemic administration.

Licensing Information

Sold with the permission of Wyeth-Ayerst Research, US Patent 4,988,814

Product Specifications for (S)-WAY 100135 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (S)-WAY 100135 dihydrochloride

The following data is based on the product molecular weight 468.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.67 mL	21.35 mL
5 mM	0.43 mL	2.13 mL	4.27 mL
10 mM	0.21 mL	1.07 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Rodgers and Cole Anxiolytic-like effect of (S)-WAY 100135, a 5-HT_1A receptor antagonist, in the murine elevated plus-maze test. Eur.J.Pharmacol. 1994 PMID: 7813555
• Fletcher WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT_1A receptors. Eur.J.Pharmacol. 1993 PMID: 8365456
• Fletcher Silent 5-HT_1A receptor antagonists: utility as research tools and therapeutic agents. Trends Pharmacol.Sci. 1993 PMID: 8122313
• Cliffe (S)-N-tert-Butyl-3(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT_1A receptors. J.Med.Chem. 1993 PMID: 8496920

Product Documents for (S)-WAY 100135 dihydrochloride