Catalog # Availability Size / Price Qty
Saclofen | CAS No. 125464-42-8 | GABA-B Receptor Antagonists
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Description: Selective GABAB antagonist

Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid

Purity: ≥99%

Product Details
Citations (10)
Supplemental Products

Biological Activity

Saclofen is a selective antagonist at GABAB receptors.

Technical Data

Soluble to 10 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. GABAB receptors and their significance in mammalian pharmacology.
    TiPS, 1989;10:401
  2. Use of the neonatal rat spinal cord in studies of the GABAB receptor.
    Jane et al.
    GABA<sub>B</sub> receptors in Mammalian Function., 1990;:42b

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Citations for Saclofen

The citations listed below are publications that use Tocris products. Selected citations for Saclofen include:

10 Citations: Showing 1 - 10

  1. Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat.
    Authors: Harte-Hargrove Et al.
    Br J Pharmacol  2015;35:1723
  2. A genetically specified connectomics approach applied to long-range feeding regulatory circuits.
    Authors: Atasoy Et al.
    Nat Neurosci  2014;17:1830
  3. Deconstruction of a neural circuit for hunger.
    Authors: Atasoy Et al.
    Mol Pain  2012;488:172
  4. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.
    Authors: Kram&#225;r Et al.
    Cereb Cortex  2009;29:12982
  5. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
    Authors: Miyazato Et al.
    J Urol  2008;179:1178
  6. PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
    Authors: Ying and Goldstein
    J Neurosci  2005;1:2
  7. BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition.
    Authors: Ohba Et al.
    Proc Natl Acad Sci U S A  2005;15:291
  8. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci  2004;24:4530
  9. Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk.
    Authors: Piet Et al.
    J Neurosci  2004;101:2151
  10. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    J Neurosci  2000;131:1050


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