Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
Biological ActivitySelective antagonist at GABAB receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
GABAB receptors and their significance in mammalian pharmacology.
Use of the neonatal rat spinal cord in studies of the GABAB receptor.
Jane et al.
GABA<sub>B</sub> receptors in Mammalian Function., 1990;:42b
Citations for Saclofen
The citations listed below are publications that use Tocris products. Selected citations for Saclofen include:
10 Citations: Showing 1 - 10
Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat.
Authors: Harte-Hargrove Et al.
Br J Pharmacol 2015;35:1723
A genetically specified connectomics approach applied to long-range feeding regulatory circuits.
Authors: Atasoy Et al.
Nat Neurosci 2014;17:1830
Deconstruction of a neural circuit for hunger.
Authors: Atasoy Et al.
Mol Pain 2012;488:172
Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.
Authors: Kramár Et al.
Cereb Cortex 2009;29:12982
GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
Authors: Miyazato Et al.
J Urol 2008;179:1178
PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
Authors: Ying and Goldstein
J Neurosci 2005;1:2
BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition.
Authors: Ohba Et al.
Proc Natl Acad Sci U S A 2005;15:291
Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
Authors: Melyan Et al.
J Neurosci 2004;24:4530
Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk.
Authors: Piet Et al.
J Neurosci 2004;101:2151
The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
Authors: Wood Et al.
J Neurosci 2000;131:1050
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