Saclofen

  ( 10 citations )    
Product Datasheet
Catalog Number:0246
Chemical Name:(RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
Product Details
Citations (10)
Supplemental Products
Reviews
Biological Activity
Selective antagonist at GABAB receptors.
Technical Data
  • M.Wt:
    249.72
  • Formula:
    C9H12ClNO3S
  • Solubility:
    Soluble to 10 mM in water
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    125464-42-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Saclofen include:

10 Citations: Showing 1 - 10
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  1. Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat.
    Authors: Harte-Hargrove Et al.
    Br J Pharmacol  2015;35:1723
  2. A genetically specified connectomics approach applied to long-range feeding regulatory circuits.
    Authors: Atasoy Et al.
    Nat Neurosci  2014;17:1830
  3. Deconstruction of a neural circuit for hunger.
    Authors: Atasoy Et al.
    Mol Pain  2012;488:172
  4. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.
    Authors: Kramár Et al.
    Cereb Cortex  2009;29:12982
  5. GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
    Authors: Miyazato Et al.
    J Urol  2008;179:1178
  6. Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
    Authors: Ying and Goldstein
    J Neurosci  2005;1:2
  7. BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition.
    Authors: Ohba Et al.
    Proc Natl Acad Sci U S A  2005;15:291
  8. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci  2004;24:4530
  9. Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk.
    Authors: Piet Et al.
    J Neurosci  2004;101:2151
  10. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    J Neurosci  2000;131:1050

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