Saquinavir mesylate

Catalog # Availability Size / Price Qty
Saquinavir mesylate | CAS No. 149845-06-7 | HIV Protease Inhibitors
1 Image
Description: HIV protease inhibitor
Alternative Names: Ro 31-8959

Chemical Name: (2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide methanesulfonate

Purity: ≥99%

Product Details
Citations (1)

Biological Activity

Saquinavir mesylate is an inhibitor of human immunodeficiency virus (HIV) protease (Ki values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CLpro.

Technical Data

Soluble to 50 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation.
    Krausslich et al.
    J.Virol., 1992;66:567
  2. A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.
    Tucker et al.
    J.Med.Chem., 1992;35:2525
  3. Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease.
    Kaldor et al.
    Bioorg.Med.Chem.Lett., 1995;5:721
  4. Rational design of peptide-based HIV proteinase inhibitors.
    Roberts et al.
    Science, 1990;248:358

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for Saquinavir mesylate

The citations listed below are publications that use Tocris products. Selected citations for Saquinavir mesylate include:

1 Citation: Showing 1 - 1


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Saquinavir mesylate

There are currently no reviews for this product. Be the first to review Saquinavir mesylate and earn rewards!

Have you used Saquinavir mesylate?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.