Chemical Name: (2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide methanesulfonate
Biological ActivityInhibitor of human immunodeficiency virus (HIV) protease (Ki values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CLpro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation.
Krausslich et al.
A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.
Tucker et al.
Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease.
Kaldor et al.
Rational design of peptide-based HIV proteinase inhibitors.
Roberts et al.
Citation for Saquinavir mesylate
The citations listed below are publications that use Tocris products. Selected citations for Saquinavir mesylate include:
1 Citation: Showing 1 - 1
Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells.
Authors: Lan Et al.
J Immunol 2014;193:3577
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