Saquinavir mesylate

Catalog # Availability Size / Price Qty
4418/10
4418/50
Saquinavir mesylate | CAS No. 149845-06-7 | Additional Synthetic Protease Inhibitors
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Description: HIV protease inhibitor
Alternative Names: Ro 31-8959

Chemical Name: (2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide methanesulfonate

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Inhibitor of human immunodeficiency virus (HIV) protease (Ki values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity.

Technical Data

M.Wt:
766.95
Formula:
C38H50N6O5.CH4O3S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
149845-06-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation.
    Krausslich et al.
    J.Virol., 1992;66:567
  2. A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.
    Tucker et al.
    J.Med.Chem., 1992;35:2525
  3. Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease.
    Kaldor et al.
    Bioorg.Med.Chem.Lett., 1995;5:721
  4. Rational design of peptide-based HIV proteinase inhibitors.
    Roberts et al.
    Science, 1990;248:358

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Citation for Saquinavir mesylate

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