Inhibitor of human immunodeficiency virus (HIV) protease (Ki
values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity.
Soluble to 50 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation.
Krausslich et al.
A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.
Tucker et al.
Rational design of peptide-based HIV proteinase inhibitors.
Roberts et al.
Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease.
Kaldor et al.
The citations listed below are publications that use Tocris products. Selected citations for Saquinavir mesylate include:
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