Catalog Number: 4418
Alternate Names: Ro 31-8959
Chemical Name: (2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide methanesulfonate
Biological Activity
Inhibitor of human immunodeficiency virus (HIV) protease (Ki values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity.
Technical Data
  • M.Wt:
    766.95
  • Formula:
    C38H50N6O5.CH4O3S
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    149845-06-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation.
    Krausslich et al.
    J.Virol., 1992;66:567
  2. A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.
    Tucker et al.
    J.Med.Chem., 1992;35:2525
  3. Rational design of peptide-based HIV proteinase inhibitors.
    Roberts et al.
    Science, 1990;248:358
  4. Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease.
    Kaldor et al.
    Bioorg.Med.Chem.Lett., 1995;5:721
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Saquinavir mesylate include:

1 Citations: Showing 1 - 1

  1. Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells.
    Authors: Lan Et al.
    J Immunol 2014;193:3577

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