Saquinavir mesylate

Key Product Details

Product Description

Saquinavir mesylate is an inhibitor of human immunodeficiency virus (HIV) protease (K_i values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CL^pro.

Product Specifications for Saquinavir mesylate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Saquinavir mesylate

The following data is based on the product molecular weight 766.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.61 mL	13.04 mL	26.08 mL
2.5 mM	0.52 mL	2.61 mL	5.22 mL
5 mM	0.26 mL	1.30 mL	2.61 mL
25 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Roberts Rational design of peptide-based HIV proteinase inhibitors. Science 1990 PMID: 2183354
• Tucker A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity. J.Med.Chem. 1992 PMID: 1635054
• Kaldor Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease. Bioorg.Med.Chem.Lett.
• Krausslich Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation. J.Virol. 1992 PMID: 1727499

Product Documents for Saquinavir mesylate