Sarpogrelate hydrochloride

Key Product Details

Product Description

Sarpogrelate hydrochloride is a selective 5-HT_2A receptor antagonist (pK_i values are 8.52, 7.43 and 6.57 for 5-HT_2A, 5-HT_2C and 5-HT_2B receptors respectively). Displays selectivity over 5-HT₁, 5-HT₃, 5-HT₄ H₁, H₂, M₃, α₁-adrenergic, α₂-adrenergic and β-adrenergic receptors. Displays cardioprotective activity in vivo.

Product Specifications for Sarpogrelate hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Sarpogrelate hydrochloride

The following data is based on the product molecular weight 465.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.73 mL	21.46 mL
5 mM	0.43 mL	2.15 mL	4.29 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Brasil Blockade of 5-HT(2A) receptors by sarpogrelate protects the heart against myocardial infarction in rats. J.Cardiovasc.Pharmacol.Ther. 2002 PMID: 12000979
• Nishiyama Acute effects of sarpogrelate, a 5-HT_2A receptor antagonist on cytokine production in endotoxin shock model of rats. Eur.J.Pharmacol. 2009 PMID: 19318092
• Rashid Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT₂ antagonist, to human 5-HT_2A, 5-HT_2B and 5-HT_2C receptor subtypes by molecular modeling. Life Sci. 2003 PMID: 12738034

Product Documents for Sarpogrelate hydrochloride