Catalog Number: 3739
Alternate Names: MCI 9042
Chemical Name: Succinic acid mono-(1-dimethylaminomethyl-2-(2-[2-(3-methoxyphenyl)ethyl]phenoxy)ethyl) ester hydrochloride
Biological Activity
Selective 5-HT2A receptor antagonist (pKi values are 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Displays selectivity over 5-HT1, 5-HT3, 5-HT4 H1, H2, M3, α1-adrenergic, α2-adrenergic and β-adrenergic receptors. Displays cardioprotective activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling.
    Rashid et al.
    Life Sci., 2003;73:193
  2. Blockade of 5-HT(2A) receptors by sarpogrelate protects the heart against myocardial infarction in rats.
    Brasil et al.
    J.Cardiovasc.Pharmacol.Ther., 2002;7:53
  3. Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine production in endotoxin shock model of rats.
    Eur.J.Pharmacol., 2009;614:122
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