Catalog Number: 1372
Chemical Name: N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-methyl-5-isothiazolyl)urea
Biological Activity
Potent and selective 5-HT2B receptor antagonist (pA2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors.
Technical Data
  • M.Wt:
    286.35
  • Formula:
    C14H14N4OS
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    152239-46-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
Background References
  1. Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease.
    Ebrahimkhani et al.
    Nat.Med., 2011;17:1668
  2. The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors.
    Bonhaus et al.
    Br.J.Pharmacol., 1995;115:622
  3. Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors.
    Glusa and Pertz
    Br.J.Pharmacol., 2000;130:692
  4. N-(1-Methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist.
    Forbes et al.
    J.Med.Chem., 1995;38:855
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 204741 include:

4 Citations: Showing 1 - 4
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  1. Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca2+-activated chloride channels.
    Authors: Salzer Et al.
    Neuropharmacology 2016;110 (A):277
  2. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci 2015;35:9580
  3. Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals.
    Authors: Hernandez Et al.
    BMC Complement Altern Med 2012;302:E1009
  4. Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B.
    Authors: Wouters Et al.
    J Biol Chem 2009;284:21177

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