SB 205384

Key Product Details

Product Description

SB 205384 is a GABA_A receptor modulator; slows current decay. Potentiates α6, α3 and α5-subunit-containing receptors (EC₅₀ values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α1 or α2 subunits.

Product Specifications for SB 205384

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 205384

The following data is based on the product molecular weight 330.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.13 mL	30.27 mL
5 mM	0.61 mL	3.03 mL	6.05 mL
10 mM	0.30 mL	1.51 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Heidelberg SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with J.Pharmacol.Exp.Ther. 2013 PMID: 23902941
• Meadows SB-205384: a GABA_A receptor modulator with novel mechanism of action that shows subunit selectivity. Br.J.Pharmacol. 1998 PMID: 9559912
• Hutcheon Developmental change in GABA_A receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J.Physiol. 2000 PMID: 10618148
• Meadows Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Br.J.Pharmacol. 1997 PMID: 9257911

Product Documents for SB 205384