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SB 205384

Catalog #: 1512
2 Citations Datasheet / COA / SDS

Discontinued Product

1512 has been discontinued.
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SB 205384 | CAS No. 160296-13-9 | GABA-A Receptor Modulators
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Description: GABAA modulator; slows current decay

Chemical Name: 4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylic acid 2-butynyl ester

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SB 205384 is a GABAA receptor modulator; slows current decay. Potentiates α6, α3 and α5-subunit-containing receptors (EC50 values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α1 or α2 subunits.

Technical Data

M.Wt:
330.4
Formula:
C17H18N2O3S
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
160296-13-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SB 205384

The citations listed below are publications that use Tocris products. Selected citations for SB 205384 include:

2 Citations: Showing 1 - 2

  1. SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits.
    Authors: Heidelberg Et al.
    J Pharmacol Exp Ther  2013;347:235
  2. Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice.
    Authors: Miller Et al.
    Sci Rep  2010;21:247

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