Chemical Name: 4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylic acid 2-butynyl ester
Biological ActivityGABAA receptor modulator; slows current decay. Potentiates α6, α3 and α5-subunit-containing receptors (EC50 values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α1 or α2 subunits.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with
Heidelberg et al.
Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum.
Meadows et al.
SB-205384: a GABAA receptor modulator with novel mechanism of action that shows subunit selectivity.
Meadows et al.
Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons.
Hutcheon et al.
Citations for SB 205384
The citations listed below are publications that use Tocris products. Selected citations for SB 205384 include:
2 Citations: Showing 1 - 2
SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits.
Authors: Heidelberg Et al.
J Pharmacol Exp Ther 2013;347:235
Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice.
Authors: Miller Et al.
Sci Rep 2010;21:247
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