SB 206553 hydrochloride

Tocris Bioscience | Catalog # 1661

Potent and selective 5-HT2B and 5-HT2C antagonist; orally active
Tocris Bioscience

Key Product Details

Description

Potent and selective 5-HT2B and 5-HT2C antagonist; orally active
View all 5-HT2C Receptor Antagonists »

Product Description

SB 206553 hydrochloride is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92). Displays > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi < 6). Centrally active following oral administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for SB 206553 hydrochloride

Molecular Weight

328.80

Formula

C17H16N4O.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide hydrochloride

CAS Number

1197334-04-5

PubChem ID

11957707

InChI Key

VGEMBOFBPSNOIO-UHFFFAOYSA-N

SMILES

Cl.CN1C=CC2=CC3=C(CCN3C(=O)NC3=CC=CN=C3)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.88 100

Preparing Stock Solutions for SB 206553 hydrochloride

The following data is based on the product molecular weight 328.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.04 mL 15.21 mL 30.41 mL
5 mM 0.61 mL 3.04 mL 6.08 mL
10 mM 0.30 mL 1.52 mL 3.04 mL
50 mM 0.06 mL 0.30 mL 0.61 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for SB 206553 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 206553 hydrochloride

For research use only

Citations for SB 206553 hydrochloride

Customer Reviews for SB 206553 hydrochloride (1)

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  • Effects of SB-206553 on MDMA-induced changes in dorsal striatal electrophysiology
    Name: Kevin Ball
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 01/25/2019
    We assessed the effect of SB-206553 (2.0 mg/kg, s.c.) on dorsal striatal single-unit electrophysiology following MDMA (ecstasy; 5.0 mg/kg) administration. A coefficient-of-variation analysis indicated significantly less variability in the magnitude of both MDMA-induced neuronal excitations and inhibitions in rats that were pretreated with SB-206553 compared to vehicle (shown in figure).
    SB 206553 hydrochloride 1661

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