SB 218078

  ( 4 citations )    
Product Datasheet
Catalog Number:2560
Chemical Name:9,10,11,12-Tetrahydro- 9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione
Product Details
Citations (4)
Reviews
Biological Activity
Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.
Technical Data
  • M.Wt:
    393.39
  • Formula:
    C24H15N3O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    135897-06-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 218078 include:

4 Citations: Showing 1 - 4
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  1. Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins.
    Authors: Colin Et al.
    PLoS One  2015;5:140156
  2. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
    Authors: Fard Et al.
    Cell Cycle  2013;13:408
  3. Host modulators of H1N1 cytopathogenicity.
    Authors: Ward Et al.
    PLoS One  2012;7:e39284
  4. Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.
    Authors: Azorsa Et al.
    J Transl Med  2009;7:43

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