SB 218078

Tocris Bioscience | Catalog # 2560

Chk1 inhibitor
Tocris Bioscience

Key Product Details

Description

Chk1 inhibitor
View all Checkpoint Kinase Inhibitors »

Product Description

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.

Product Specifications for SB 218078

Molecular Weight

393.39

Formula

C24H15N3O3

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

9,10,11,12-Tetrahydro- 9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione

CAS Number

135897-06-2

PubChem ID

3387354

InChI Key

OTPNDVKVEAIXTI-UHFFFAOYSA-N

SMILES

O=C1NC(=O)C2=C1C1=C3N(C4CCC(O4)N4C5=C(C=CC=C5)C2=C34)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.34 100

Preparing Stock Solutions for SB 218078

The following data is based on the product molecular weight 393.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.42 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

Product Documents for SB 218078

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 218078

For research use only

Customer Reviews for SB 218078 (1)

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  • Combinatorial treatments
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/13/2022
    Combinatorial treatments of SB 218078 with chemotherapeutic drugs resulted in enhanced cytotoxicity in pancreatic and glioma cell lines

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