SB 224289 hydrochloride

  ( 7 citations )    
Product Datasheet
Catalog Number:1221
Chemical Name:1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine hydrochloride
Product Details
Citations (7)
Supplemental Products
Reviews
Biological Activity
Selective 5-HT1B receptor antagonist (pKi = 8.2). Displays > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo.
Technical Data
  • M.Wt:
    557.09
  • Formula:
    C32H32N4O3.HCl
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
    >95
  • Storage:
    Store at -20°C
  • CAS No:
    180084-26-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 224289 hydrochloride include:

7 Citations: Showing 1 - 7
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  1. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
    Authors: Hirono
    Neuropharmacology  2017;118:79
  2. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
    Authors: Cassilly Et al.
    Mol Ther  2016;11:e0154932
  3. Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres.
    Authors: Baillie Et al.
    PLoS One  2012;63:362
  4. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension.
    Authors: Morecroft Et al.
    Neuron  2012;20:1516
  5. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
    Authors: Murray Et al.
    J Neurophysiol  2011;106:925
  6. Serotonin reciprocally regulates melanocortin neurons to modulate food intake.
    Authors: Heisler Et al.
    J Neurosci  2006;51:239
  7. The role of serotonin (5-hydroxytryptamine1A and 1B) receptors in prostate cancer cell proliferation.
    Authors: Siddiqui Et al.
    J Urol  2006;176:1648

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