SB 224289 hydrochloride

Tocris Bioscience | Catalog # 1221

Selective 5-HT1B antagonist
Tocris Bioscience

Key Product Details

Description

Selective 5-HT1B antagonist
View all 5-HT1B Receptor Antagonists »

Product Description

SB 224289 hydrochloride is a selective 5-HT1B receptor antagonist (pKi = 8.2). Displays > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications for SB 224289 hydrochloride

Molecular Weight

557.09

Formula

C32H32N4O3.HCl

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine hydrochloride

CAS Number

180084-26-8

PubChem ID

11226716

InChI Key

GKGKBZYMDILCOF-UHFFFAOYSA-N

SMILES

O=C(C5=CC=C(C6=CC=C(C7=NOC(C)=N7)C=C6C)C=C5)N2C1=CC3=C(OCC43CCN(CC4)C)C=C1CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.57 10 with gentle warming

Preparing Stock Solutions for SB 224289 hydrochloride

The following data is based on the product molecular weight 557.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.95 mL 89.75 mL 179.50 mL
0.5 mM 3.59 mL 17.95 mL 35.90 mL
1 mM 1.80 mL 8.98 mL 17.95 mL
5 mM 0.36 mL 1.80 mL 3.59 mL

Calculators

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Product Documents for SB 224289 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 224289 hydrochloride

For research use only

Citations for SB 224289 hydrochloride

Customer Reviews for SB 224289 hydrochloride (1)

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  • The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound
    Name: Anonymous
    Species: C. albicans
    Assay Type: In Vitro
    Verified Customer | Posted 02/01/2020
    Biologically active compounds that have been documented to interact with a wide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat. # 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience
    SB 224289 hydrochloride 1221

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