SB 258585 hydrochloride

Key Product Details

Product Description

SB 258585 hydrochloride is a potent and selective 5-HT₆ receptor antagonist (pK_i = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for SB 258585 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 258585 hydrochloride

The following data is based on the product molecular weight 523.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.82 mL	19.09 mL	38.18 mL
2.5 mM	0.76 mL	3.82 mL	7.64 mL
5 mM	0.38 mL	1.91 mL	3.82 mL
25 mM	0.08 mL	0.38 mL	0.76 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• East 5-HT₆ receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [¹²⁵I]SB-258585. Synapse 2002 PMID: 12112397
• Hirst Characterization of [¹²⁵I]-SB-258585 binding to human recombinant and native 5-HT₆ receptors in rat, pig and human brain tissue. Br.J.Pharmacol. 2000 PMID: 10928963
• Bromidge 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): a potent, selective, and orally bioavailable 5-HT₆ receptor antagonist. J.Med.Chem. 1999 PMID: 9925723

Product Documents for SB 258585 hydrochloride