Catalog Number: 1961
Chemical Name: 4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide hydrochloride
Biological Activity
Potent and selective 5-HT6 receptor antagonist (pKi = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.
Technical Data
  • M.Wt:
    523.82
  • Formula:
    C18H22IN3O3S.HCl
  • Solubility:
    Soluble to 10 mM in water and to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    1216468-02-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.
    Bromidge et al.
    J.Med.Chem., 1999;42:202
  2. Characterization of [125I]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue.
    Hirst et al.
    Br.J.Pharmacol., 2000;130:1597
  3. 5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585.
    East et al.
    Synapse, 2002;45:191
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 258585 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptor.
    Authors: Yun Et al.
    Scientific Reports 2016;6:30985

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