Potent and selective 5-HT6
receptor antagonist (pKi
= 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.
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All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from GlaxoSmithKline
5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.
Bromidge et al.
Characterization of [125I]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue.
Hirst et al.
5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585.
East et al.
The citations listed below are publications that use Tocris products. Selected citations for SB 258585 hydrochloride include:
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