SB 258719 hydrochloride

Key Product Details

Product Description

SB 258719 hydrochloride is a selective 5-HT₇ receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for SB 258719 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 258719 hydrochloride

The following data is based on the product molecular weight 374.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.33 mL	26.67 mL
5 mM	0.53 mL	2.67 mL	5.33 mL
10 mM	0.27 mL	1.33 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Thomas Functional characterisation of the human cloned 5-HT₇ receptor (long form); antagonist profile of SB-258719. Br.J.Pharmacol. 1998 PMID: 9720804
• Guscott The hypothermic effect of 5-CT in mice is mediated through the 5-HT₇receptor. Neuropharmacology 2003 PMID: 12763096
• Forbes (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)propyl]benzenesulfonamide: the first selective 5-HT₇ receptor antagonist. J.Med.Chem. 1998 PMID: 9513592

Product Documents for SB 258719 hydrochloride