SB 258719 hydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:2726
Chemical Name:3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Selective 5-HT7 receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration.
Technical Data
  • M.Wt:
    374.97
  • Formula:
    C18H30N2O2S.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    1217674-10-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 258719 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis.
    Authors: Dom?nguez-Soto
    Sci Rep  2017;7(1):14761
  2. Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system.
    Authors: Zhao Et al.
    Front Synaptic Neurosci  2015;5:9043
  3. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster.
    Authors: Johnson Et al.
    Neuroscience  2011;192:372

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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human 5-HT7 (NP_000863) VersaClone cDNA

RDC0251
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Human 5-HT7 (NP_062874) VersaClone cDNA

RDC0252
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