receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration.
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(R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist.
Forbes et al.
Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719.
Thomas et al.
The hypothermic effect of 5-CT in mice is mediated through the 5-HT7receptor.
Guscott et al.
The citations listed below are publications that use Tocris products. Selected citations for SB 258719 hydrochloride include:
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