Catalog Number: 2726
Chemical Name: 3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride
Biological Activity
Selective 5-HT7 receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration.
Technical Data
  • M.Wt:
    374.97
  • Formula:
    C18H30N2O2S.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    1217674-10-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist.
    Forbes et al.
    J.Med.Chem., 1998;41:655
  2. Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719.
    Thomas et al.
    Br.J.Pharmacol., 1998;124:1300
  3. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7receptor.
    Guscott et al.
    Neuropharmacology, 2003;44:1031
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 258719 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system.
    Authors: Zhao Et al.
    Front Synaptic Neurosci 2015;5:9043
  2. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster.
    Authors: Johnson Et al.
    Neuroscience 2011;192:372

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