Catalog Number: 4314
Chemical Name: N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide
Biological Activity
Selective non-peptide CGRP1 antagonist. Inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively).
Technical Data
  • M.Wt:
    401.46
  • Formula:
    C18H15N3O4S2
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    217438-17-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline.
Background References
  1. Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist.
    Aiyar et al.
    J.Pharmacol.Exp.Ther., 2001;296:768

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