SB 297006

Catalog # Availability Size / Price Qty
4213/10
4213/50
SB 297006 | CAS No. 58816-69-6 | Chemokine Receptor Antagonists
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Description: Potent and selective CCR3 antagonist

Chemical Name: N-Benzoyl-4-nitroaniline ethyl ester

Purity: ≥99%

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Biological Activity

Potent and selective CCR3 antagonist (IC50 = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC50 >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC50 values are 80, 90 and 210 nM respectively).

Technical Data

M.Wt:
342.35
Formula:
C18H18N2O5
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
58816-69-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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