SB 328437

Catalog # Availability Size / Price Qty
3650/10
3650/50
SB 328437 | CAS No. 247580-43-4 | Chemokine Receptor Antagonists
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Description: Potent and selective CCR3 antagonist

Chemical Name: N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanine methyl ester

Purity: ≥99%

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Biological Activity

Potent and selective CCR3 antagonist (IC50 = 4 nM). Displays > 2500-fold selectivity over C5aR, LTD4, CCR7, CXCR1 and CXCR2 receptors. Inhibits eotaxin-, eotaxin-2- and MCP-4-induced Ca2+ mobilization (IC50 values are 38, 35 and 20 nM respectively) and inhibits eotaxin-, eotaxin-2- and MCP-4-induced eosinophil chemotaxis with similar potencies.

Technical Data

M.Wt:
378.38
Formula:
C21H18N2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
247580-43-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration.
    White et al.
    J.Biol.Chem., 2000;275:36626
  2. Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists.
    Mori et al.
    Int.Immunol., 2007;19:913
  3. Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation.
    Abonyo et al.
    Am.J.Physiol.Lung Cell.Mole.Physiol., 2005;289:L478

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