SB 332235

Catalog # Availability Size / Price Qty
5671/10
5671/50
Cat.No. 5671 - SB 332235 | C13H10Cl3N3O4S | CAS No. 276702-15-9
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Description: Potent CXCR2 antagonist

Chemical Name: 6-Chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxybenzenesulfonamide

Purity: ≥98%

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Biological Activity

Potent CXCR2 antagonist (IC50 = 7.7 nM). Exhibits 285-fold selectivity for CXCR2 over CXCR1. Reduces leukocyte numbers in synovial fluid in acute and chronic rabbit arthritis models. Also reduces synovial fluid eicosanoid and cytokine levels in a rabbit chronic arthritis model. Inhibits proliferation of AML cell lines in vitro.

Technical Data

M.Wt:
410.66
Formula:
C13H10Cl3N3O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
276702-15-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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