Chemical Name: 6-Chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxybenzenesulfonamide
Biological ActivitySB 332235 is a potent CXCR2 antagonist (IC50 = 7.7 nM). Exhibits 285-fold selectivity for CXCR2 over CXCR1. Reduces leukocyte numbers in synovial fluid in acute and chronic rabbit arthritis models. Also reduces synovial fluid eicosanoid and cytokine levels in a rabbit chronic arthritis model. Inhibits proliferation of AML cell lines in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit.
Podolin et al.
IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells.
Schinke et al.
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