SB 332235

   
Product Datasheet
Catalog Number:5671
Chemical Name:6-Chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxybenzenesulfonamide
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Biological Activity
Potent CXCR2 antagonist (IC50 = 7.7 nM). Exhibits 285-fold selectivity for CXCR2 over CXCR1. Reduces leukocyte numbers in synovial fluid in acute and chronic rabbit arthritis models. Also reduces synovial fluid eicosanoid and cytokine levels in a rabbit chronic arthritis model. Inhibits proliferation of AML cell lines in vitro.
Technical Data
  • M.Wt:
    410.66
  • Formula:
    C13H10Cl3N3O4S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    276702-15-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human CXCR2/IL-8 RB (AAB25880) VersaClone cDNA

RDC0027
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Rat CXCR2/IL-8 RB (NP_058879) VersaClone cDNA

RDC0242
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Mouse CXCR2/IL-8 RB (NP_034039) VersaClone cDNA

RDC0028
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