Catalog Number: 3265
Chemical Name: N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]-urea
Biological Activity
Potent TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22 at the recombinant hTRPV1 receptor). Exhibits analgesic properties.
Technical Data
  • M.Wt:
    376.29
  • Formula:
    C18H22BrN3O
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    459429-39-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes only under agreement from GlaxoSmithKline
Background References
  1. Discovery of small molecule antagonists of TRPV1.
    Rami et al.
    Bioorg.Med.Chem.Lett., 2004;14:3631
  2. Conservation of functional and pharmacological properties in the distantly related temperature sensors TRPV1 and TRPM8.
    Weil et al.
    Mol.Pharmacol., 2005;68:518
  3. [3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-ylurea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor.
    Bianchi et al.
    J.Pharmacol.Exp.Ther., 2007;323:285
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 452533 include:

1 Citations: Showing 1 - 1

  1. Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers.
    Authors: Vijayvergiya Et al.
    Mol Pain 2015;10:e0141366

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