SB 452533

Catalog # Availability Size / Price Qty
3265/10
3265/50
SB 452533 | CAS No. 459429-39-1 | TRPV Antagonists
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Description: Potent TRPV1 receptor antagonist

Chemical Name: N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]-urea

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews

Biological Activity

Potent TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22 at the recombinant hTRPV1 receptor). Exhibits analgesic properties.

Technical Data

M.Wt:
376.29
Formula:
C18H22BrN3O
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at RT
CAS No:
459429-39-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes only under agreement from GlaxoSmithKline

Product Datasheets

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Citation for SB 452533

The citations listed below are publications that use Tocris products. Selected citations for SB 452533 include:

1 Citation: Showing 1 - 1

  1. Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers.
    Authors: Vijayvergiya Et al.
    Mol Pain  2015;10:e0141366

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