SB 747651A dihydrochloride

Catalog # Availability Size / Price Qty
4630/10
SB 747651A dihydrochloride | CAS No. 1781882-72-1 | Other Kinase Inhibitors
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Description: Potent MSK1 inhibitor; also inhibits other AGC group kinases

Chemical Name: 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride

Purity: ≥98%

Product Details
Citations (3)
Reviews (2)

Biological Activity

SB 747651A dihydrochloride is a potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells. Blocks IL-10 production in macrophages.

Technical Data

M.Wt:
415.32
Formula:
C16H22N8O.2HCl
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1781882-72-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline.

Product Datasheets

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Citations for SB 747651A dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SB 747651A dihydrochloride include:

3 Citations: Showing 1 - 3

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Reviews for SB 747651A dihydrochloride

Average Rating: 4.5 (Based on 2 Reviews)

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inhibition of IL10
By Anonymous on 04/23/2021
Application: Species: Mouse

In vitro, inhibition of IL10


In vitro study
By Anonymous on 12/22/2020
Application: Species: Mouse

In vitro study of MSK1 in pancreatic cancer


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