SB 747651A dihydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:4630
Chemical Name:2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride
Product Details
Citations (1)
Reviews
Biological Activity
Potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells. Blocks IL-10 production in macrophages.
Technical Data
  • M.Wt:
    415.32
  • Formula:
    C16H22N8O.2HCl
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    1781882-72-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 747651A dihydrochloride include:

1 Citations: Showing 1 - 1

  1. The mitogen and stress-activated protein kinase 1 regulates the rapid epigenetic tagging of dorsal horn neurons and nocifensive behaviour.
    Authors: Tochiki Et al.
    Pain  2016;157:2594

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