SB 747651A dihydrochloride

Catalog # Availability Size / Price Qty
4630/10
Cat.No. 4630 - SB 747651A dihydrochloride | C16H22N8O.2HCl | CAS No. 1781882-72-1
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Description: Potent MSK1 inhibitor; also inhibits other AGC group kinases

Chemical Name: 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells. Blocks IL-10 production in macrophages.

Technical Data

M.Wt:
415.32
Formula:
C16H22N8O.2HCl
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1781882-72-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline.

Product Datasheets

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Citation for SB 747651A dihydrochloride

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