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SB 747651A dihydrochloride

4630 3 Citations Datasheet / COA / SDS
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SB 747651A dihydrochloride | CAS No. 1781882-72-1 | Other Kinase Inhibitors
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Description: Potent MSK1 inhibitor; also inhibits other AGC group kinases

Chemical Name: 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells. Blocks IL-10 production in macrophages.

Technical Data

M.Wt:
415.32
Formula:
C16H22N8O.2HCl
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1781882-72-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline.

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Citations for SB 747651A dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SB 747651A dihydrochloride include:

3 Citations: Showing 1 - 3

  1. MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sj�gren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1.
    Authors: Lopes Et al.
    Front Immunol  2019;10:1335
  2. Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.
    Authors: Jones Et al.
    Sci Signal  2018;11
  3. The mitogen and stress-activated protein kinase 1 regulates the rapid epigenetic tagging of dorsal horn neurons and nocifensive behaviour.
    Authors: Tochiki Et al.
    Pain  2016;157:2594

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