SB 747651A dihydrochloride

Tocris Bioscience | Catalog # 4630

Potent MSK1 inhibitor; also inhibits other AGC group kinases
Tocris Bioscience

Key Product Details

Description

Potent MSK1 inhibitor; also inhibits other AGC group kinases
View all Other Kinase Inhibitors »

Product Description

SB 747651A dihydrochloride is a potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells. Blocks IL-10 production in macrophages.

Licensing Information

Sold with the permission of GlaxoSmithKline.

Product Specifications for SB 747651A dihydrochloride

Molecular Weight

415.32

Formula

C16H22N8O.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride

CAS Number

1781882-72-1

PubChem ID

90488958

InChI Key

NRRCQHARLPNLHJ-UHFFFAOYSA-N

SMILES

NC1=NON=C1C3=NC2=CN=CC(CNC4CCNCC4)=C2N3CC.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.77 50
DMSO 20.77 50

Preparing Stock Solutions for SB 747651A dihydrochloride

The following data is based on the product molecular weight 415.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.82 mL 24.08 mL 48.16 mL
2.5 mM 0.96 mL 4.82 mL 9.63 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
25 mM 0.10 mL 0.48 mL 0.96 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

Product Documents for SB 747651A dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 747651A dihydrochloride

For research use only

Citations for SB 747651A dihydrochloride

Customer Reviews for SB 747651A dihydrochloride (3)

4.3 out of 5
3 Customer Ratings
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4 Stars
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Showing  1 - 3 of 3 reviews Showing All
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  • In vitro study
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 09/29/2021
    IL10 inhibition
  • inhibition of IL10
    Name: Puru Lamichhane
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 04/23/2021
    In vitro, inhibition of IL10
  • In vitro study
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 12/22/2020
    In vitro study of MSK1 in pancreatic cancer

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