SC 144 hydrochloride
Chemical Name: 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride
Biological ActivitySC 144 hydrochloride is an inhibitor of gp130 (IC50 = 0.72 μM); blocks cytokine-triggered gp130 signaling. SC 144 hydrochloride induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. SC 144 hydrochloride delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.
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Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer.
Xu et al.
Mol.Cancer Ther., 2013;12:937
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