SC 144 hydrochloride

Tocris Bioscience | Catalog # 4963

gp130 inhibitor; blocks cytokine-triggered gp130 signaling
Tocris Bioscience

Key Product Details

Description

gp130 inhibitor; blocks cytokine-triggered gp130 signaling
View all Cytokine Compounds »

Product Description

SC 144 hydrochloride is an inhibitor of gp130 (IC50 = 0.72 μM); blocks cytokine-triggered gp130 signaling. SC 144 hydrochloride induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. SC 144 hydrochloride delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.

Product Specifications for SC 144 hydrochloride

Molecular Weight

358.76

Formula

C16H11FN6O.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride

CAS Number

917497-70-2

PubChem ID

66921431

InChI Key

LKFGGXYXFIICED-UHFFFAOYSA-N

SMILES

O=C(C4=CN=CC=N4)NNC1=NC(C=C(F)C=C3)=C3N2C1=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.23 100

Preparing Stock Solutions for SC 144 hydrochloride

The following data is based on the product molecular weight 358.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.94 mL 27.87 mL
5 mM 0.56 mL 2.79 mL 5.57 mL
10 mM 0.28 mL 1.39 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for SC 144 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SC 144 hydrochloride

For research use only

Citations for SC 144 hydrochloride

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